Chlorogenic and Caftaric Acids in Liver Toxicity and Oxidative Stress Induced by Methamphetamine

Table 1

Effect of chlorogenic and caftaric acids on serums AST, ALT, total bilirubin, and ALP of METH-injected rats.

Groups	Parameters
	AST; (U/L)	ALT; (U/L)	Total bilirubin; (mg/dL)	ALP; (U/L)
Control	123.1 ± 3.85	62.5 ± 2.48	0.56 ± 0.08	210.5 ± 6.81
METH group	140.2 ± 0.72*	82.0 ± 1.96**	0.75 ± 0.05**	241.2 ± 7.15**
Chlorogenic acid + METH group	125.4 ± 4.17^a	60.1 ± 2.9^b	0.58 ± 0.04^b	215.1 ± 6.59^b
Caftaric acid + METH group	128.3 ± 3.94^a	65.0 ± 2.87^b	0.60 ± 0.07^a	223.0 ± 4.86^a

Data presented as mean ± SE. Number of animals = 8 per group.
*Significant change (𝑃≤0.05) compared to control rats.
**Highly significant change (𝑃≤0.01) compared to control rats.
^aSignificant change (𝑃≤0.05) compared to METH group.
^bHighly significant change (𝑃≤0.01) compared to METH group.