Journal of Toxicology / 2014 / Article / Tab 5

Research Article

Chlorogenic and Caftaric Acids in Liver Toxicity and Oxidative Stress Induced by Methamphetamine

Table 5

Effect of chlorogenic and caftaric acids on liver SOD, GPx, MDA, and NO of METH-injected rats.

Groups Parameters
SOD
(mU/mg tissue)
GPx
(mU/mg tissue)
MDA
(nmol/100 mg tissue)
NO
(µmol/mg tissue)

Control137.85 ± 12.193.69 ± 0.1629.57 ± 3.164.83 ± 1.51
METH group65.87 ± 9.42**1.12 ± 0.41**56.85 ± 4.15**8.24 ± 1.29**
Chlorogenic acid + METH group136.87 ± 12.64b3.58 ± 0.20b30.65 ± 2.47b4.95 ± 1.32b
Caftaric acid + METH group129.56 ± 13.16a3.48 ± 0.37b34.25 ± 3.85a5.21 ± 1.49a

Data presented as mean ± SE. Number of animals = 8 per group.
*Significant change compared to control rats.
**Highly significant change compared to control rats.
aSignificant change compared to METH group.
bHighly significant change compared to METH group.