Chlorogenic and Caftaric Acids in Liver Toxicity and Oxidative Stress Induced by Methamphetamine

Table 5

Effect of chlorogenic and caftaric acids on liver SOD, GPx, MDA, and NO of METH-injected rats.

Groups	Parameters
	SOD; (mU/mg tissue)	GPx; (mU/mg tissue)	MDA; (nmol/100 mg tissue)	NO; (µmol/mg tissue)
Control	137.85 ± 12.19	3.69 ± 0.16	29.57 ± 3.16	4.83 ± 1.51
METH group	65.87 ± 9.42**	1.12 ± 0.41**	56.85 ± 4.15**	8.24 ± 1.29**
Chlorogenic acid + METH group	136.87 ± 12.64^b	3.58 ± 0.20^b	30.65 ± 2.47^b	4.95 ± 1.32^b
Caftaric acid + METH group	129.56 ± 13.16^a	3.48 ± 0.37^b	34.25 ± 3.85^a	5.21 ± 1.49^a

Data presented as mean ± SE. Number of animals = 8 per group.
*Significant change (𝑃≤0.05) compared to control rats.
**Highly significant change (𝑃≤0.01) compared to control rats.
^aSignificant change (𝑃≤0.05) compared to METH group.
^bHighly significant change (𝑃≤0.01) compared to METH group.