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Journal of Toxicology
Volume 2014, Article ID 917608, 7 pages
http://dx.doi.org/10.1155/2014/917608
Research Article

Camel Milk Beneficial Effects on Treating Gentamicin Induced Alterations in Rats

1Department of Research Center, Prince Sultan Military Medical City, P.O. Box 7897 (775-S), Riyadh 11159, Saudi Arabia
2Department of Urology, Prince Sultan Military Medical City, P.O. Box 7897, Riyadh 11159, Saudi Arabia
3Department of Surgery, Prince Sultan Military Medical City, P.O. Box 7897, Riyadh 11159, Saudi Arabia
4Department of F & C Medicine, Prince Sultan Military Medical City, P.O. Box 7897, Riyadh 11159, Saudi Arabia
5Department of Dentistry, Prince Sultan Military Medical City, P.O. Box 7897, Riyadh 11159, Saudi Arabia

Received 18 May 2014; Revised 10 November 2014; Accepted 10 November 2014; Published 3 December 2014

Academic Editor: Margaret James

Copyright © 2014 Abdulrahman K. Al-Asmari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The potential effect of camel milk (CM) against gentamicin (GM) induced biochemical changes in the rat serum was evaluated. Four groups of six albino rats were used for control, CM fed, injected with GM(i.p.), and then fed and injected with GM. The results showed that the administration of GM significantly altered the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) activity in rat serum. CM restored these parameters to almost their normal range in group IV. Additionally, the present study showed that injection of rats with gentamicin caused an increase in malondialdehyde (MDA) and myeloperoxidase (MPO) activity while the antioxidant enzymes like superoxide dismutase (SOD) and glutathione s-transferase (GST) activity decreased significantly (). Administration of CM significantly () inhibited the formation of MDA and activity of MPO and upregulated the antioxidant enzymes (SOD and GST) activity. The overall findings of this study demonstrated that pretreatment with CM gave protection against GM induced hepatic damage possibly by inhibiting oxidative stress and inflammation, and hence camel milk can be identified as a new therapeutic agent.