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Journal of Toxicology
Volume 2014, Article ID 946372, 4 pages
Research Article

The Toxic Effect of Manganese on the Acetylcholinesterase Activity in Rat Brains

1Department of Biology, Faculty of Sciences, Payame Noor University, Iran
2Department of Biochemistry, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran
3Department of Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
4Department of Biology, Payame Noor University, Tehran, Iran
5Department of Food Safety and Hygiene, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Received 8 June 2014; Revised 13 August 2014; Accepted 13 August 2014; Published 26 August 2014

Academic Editor: Syed Ali

Copyright © 2014 Vahid Yousefi Babadi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Manganese (Mn) is a naturally occurring element and an essential nutrient for humans and animals. However, exposure to high levels of Mn may cause neurotoxic effects. Accumulation of manganese damages central nervous system and causes Parkinson’s disease-like syndrome called manganism. Mn neurotoxicity has been suggested to involve an imbalance between the DAergic and cholinergic systems. The pathological mechanisms associated with Mn neurotoxicity are poorly understood, but several reports have established it is mediated by changing of AChE activity that resulted in oxidative stress. Therefore we focused the effect of Mn in AChE activity in the rat’s brain by MnCl2 injection intraperitoneally and analyzed their brains after time intervals. This study used different acute doses in short time course and different chronic doses at different exposing time to investigate which of them (exposing dose or time) is more important in Mn toxic effect. Results showed toxic effect of Mn is highly dose dependent and AChE activity in presence of chronic dose in 8 weeks reaches acute dose in only 2 days.