Research Article

Effect of Metformin and Sitagliptin on Doxorubicin-Induced Cardiotoxicity in Rats: Impact of Oxidative Stress, Inflammation, and Apoptosis

Table 2

Effect of metformin or sitagliptin on the histopathology in DOX-induced cardiotoxicity in rats.

ParameterControlMetforminSitagliptinDOXMetformin/DOXSitagliptin/DOX

Myocardial degeneration0 ± 00 ± 00 ± 02.00 ± 0.270.25 ± 0.040.50 ± 0.03
Interstitial inflammation0 ± 00 ± 00 ± 02.75 ± 0.320.50 ± 0.021.00 ± 0.07
Interstitial hemorrhage0 ± 00 ± 00 ± 02.25 ± 0.210.75 ± 0.030.50 ± 0.02

Data were expressed as mean ± SEM of six observations.
Significantly different from control group ().
Significantly different from doxorubicin group ().