Evaluation of Possible Genotoxic Activity of Dirithromycin in Cultured Human Lymphocytes

Table 1

Frequency of sister chromatid exchanges (SCEs/cell) and replication index (RI) in cultured human lymphocytes treated with dirithromycin and controls.

Test substance	Treatment		Min-max	SCEs/cell ± SE	RI ± SE
	Time (h)	Cons. (µg/mL)	SCE
Control		0.0	1–7	4.89 ± 0.34	2.33 ± 0.11
Control (+)		0.1	8–39	30.22 ± 1.60	1.76 ± 0.12
Dirithromycin	24	37.75	1–9	6.34 ± 0.33	2.15 ± 0.21
		67.50	1–9	6.54 ± 0.43	2.16 ± 0.13
		125.00	1–10	6.70 ± 0.35	1.93 ± 0.13
		250.00	2–12	7.92 ± 0.22	2.00 ± 0.10
Control		0.0	1–8	4.89 ± 0.34	2.33 ± 0.11
Control (+)		0.1	8–40	58.59 ± 0.88	1.57 ± 0.09
Dirithromycin	48	37.75	1–9	6.58 ± 0.32	2.28 ± 0.05
		67.50	1–11	7.28 ± 0.23	2.34 ± 0.06
		125.00	1–12	7.95 ± 0.26	2.30 ± 0.04
		250.00	1–13	8.02 ± 0.20	2.31 ± 0.04

SE: standard error.
Control (+): Mitomycin-C as positive control.
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