Evaluation of Possible Genotoxic Activity of Dirithromycin in Cultured Human Lymphocytes

Table 2

Frequency of chromosomal abnormalities (CA/cell), abnormal cells (Ab.C), and mitotic index (MI) in cultured human lymphocytes treated with dirithromycin and controls.

Test substance	Treatment		CA/cell ± SE	Ab.C ± SE	MI ± SE
	Time (h)	Cons. (µg/mL)		(%)
Control		0.0	0.06 ± 0.00	6.75 ± 0.25	0.04 ± 0.01
Control (+)		0.1	0.22 ± 0.03	21.50 ± 3.22	0.02 ± 0.00
Dirithromycin	24	37.75	0.09 ± 0.01	9.00 ± 1.22	0.05 ± 0.00
		67.50	0.14 ± 0.02	13.75 ± 1.88	0.04 ± 0.00
		125.00	0.17 ± 0.01	17.50 ± 1.32	0.04 ± 0.00
		250.00	0.21 ± 0.01	21.00 ± 1.22	0.04 ± 0.00
Control		0.0	0.06 ± 0.00	6.75 ± 0.25	0.03 ± 0.00
Control (+)		0.1	0.33 ± 0.04	32.50 ± 3.01	0.02 ± 0.00
Dirithromycin	48	37.75	0.16 ± 0.01	15.25 ± 1.49	0.05 ± 0.00
		67.50	0.17 ± 0.01	17.00 ± 1.29	0.07 ± 0.02
		125.00	0.20 ± 0.02	19.50 ± 1.50	0.07 ± 0.01
		250.00	0.28 ± 0.03	27.75 ± 4.15	0.06 ± 0.02

Control (+): Mitomycin-C as positive control.
; .