Evaluation of Possible Genotoxic Activity of Dirithromycin in Cultured Human Lymphocytes
Table 3
Frequency of micronuclei (MNs), binucleated cells with MN (BNMN), and nuclear division index (NDI) in cultured human lymphocytes treated with dirithromycin and controls.
Test substance
Treatment
MN ± SE ()
BNMN ± SE ()
NDI ± SE
Time (h)
Cons. (µg/mL)
Control
0.0
6.00 ± 0.40
6.00 ± 0.40
1.19 ± 0.02
Control (+)
0.1
21.00 ± 1.77
18.00 ± 1.47
1.11 ± 0.01
Dirithromycin
24
37.75
9.25 ± 0.62
9.75 ± 1.10
1.17 ± 0.01
67.50
11.25 ± 1.18
10.50 ± 0.95
1.16 ± 0.02
125.00
13.25 ± 0.62
12.75 ± 0.47
1.16 ± 0.02
250.00
18.50 ± 0.64
14.50 ± 0.64
1.14 ± 0.00
Control
0.0
6.00 ± 0.40
6.00 ± 0.40
1.19 ± 0.02
Control (+)
0.1
49.50 ± 3.12
46.00 ± 2.16
1.11 ± 0.00
Dirithromycin
48
37.75
14.00 ± 0.70
10.50 ± 0.50
1.25 ± 0.02
67.50
15.25 ± 0.85
13.25 ± 0.47
1.23 ± 0.03
125.00
14.50 ± 0.64
13.00 ± 0.40
1.42 ± 0.16
250.00
15.50 ± 0.64
15.00 ± 0.70
1.25 ± 0.00
Control (+): Mitomycin-C as positive control. ; ; .
