Neuroprotective Effects of Alpha-Mangostin on MPP+-Induced Apoptotic Cell Death in Neuroblastoma SH-SY5Y Cells
Effect of alpha-mangostin on the MPP+-induced apoptosis in SH-SY5Y cells. Cells were exposed to 10 μM of alpha-mangostin (α-M), 1000 μM MPP+, or a combination of α-M and MPP+ for 24 hours. Apoptosis was evaluated by staining cells with annexin-V. Flow cytometry profile represents annexin-V-FITC staining in -axis and PI in -axis (a). The number in the right upper quadrant (annexin-V+/PI+ cells) represents the percentage of late apoptotic/necrotic cells in each condition. Percentage of annexin-V-positive cells was calculated (b). Data are expressed as mean ± SEM () of percentage to untreated cells. .
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