Histopathological Study of Cyclosporine Pulmonary Toxicity in Rats

Figure 3

(a) A photomicrograph of transverse section in the control rat lung shows normal distribution of fibrous tissues and architecture of alveoli (A) with thin interalveolar septa (s) and normal interstitial tissues (I) (Mallory ×400). (b) A photomicrograph of transverse section in the second group rat lung shows mild distribution of fibrous tissues around alveoli (A) with thickening of the interalveolar septa (IS) and bronchiole (B) (Mallory ×400). (c) A photomicrograph of transverse section in the third group rat lung shows loss of normal architecture, increase of fibrous tissues around alveoli (A), subsequent compensatory dilatation of other alveoli, marked thinning of the interalveolar septum (s) with an increase of fibrous tissues in the areas of interstitial tissues (IS), and thickened and congested pulmonary blood vessels which contain hemorrhagic blood cells (bv) (Mallory ×400).