Histopathological Study of Cyclosporine Pulmonary Toxicity in Rats

Table 2

Comparison between effects of cyclosporine different doses on the rats’ lung histopathological parameters.

Parameter	Group
	First	Second	Third
	M ± SD	M ± SD	M ± SD
Oedema	0.1 ± 0.1	1.1 ± 0.5	1.7 ± 0.5
Hemorrhage	0.4 ± 0.8	2.0 ± 0.9	3.3 ± 0.4
Cell infiltration	0.2 ± 0.8	4.1 ± 0.5	5.6 ± 0.3
Alveolar septal thickening	0.1 ± 0.3	2.9 ± 0.5	2.4 ± 0.3
Total score	0.2 ± 0.4	2.52 ± 0.6	3.25 ± 0.4

First group: physiological saline (control).
Second group: cyclosporine (25 mg/kg/day).
Third group: cyclosporine (40 mg/kg/day).
M ± SD: mean ± standard deviation. Number per group: 20
⁢: significant difference in comparison with the control group
⁢: significant difference in comparison with the second group.