Journal of Toxicology / 2016 / Article / Tab 1

Research Article

A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

Table 1

Summary of necropsy findings.

OrganObservationsMales (mg/kg bw/d)Females (mg/kg bw/d)
Control180300375Control180300375
Died earlySurvivorsDied earlySurvivors

No macroscopic findings10/109/106/100/10/99/106/100/26/83/10
TestesSmaller than normal0/100/104/101/19/9/////
EpididymidesSmaller than normal0/100/104/100/19/9/////
ProstateSmaller than normal0/100/100/100/13/9/////
Adrenal glandsPale0/100/102/100/17/90/100/100/20/84/10
Enlarged0/100/100/100/10/90/100/101/20/80/10
Kidney (left side)White compact formation on the surface0/100/100/100/11/90/100/100/20/80/10
SkinAlopecia0/101/101/100/10/90/100/100/20/80/10
Scar0/100/101/100/12/90/100/100/20/80/10
Cyanotic0/100/100/101/10/90/100/100/20/80/10
LiverDark red0/100/100/101/10/90/100/102/20/80/10
LungsDark red0/100/100/101/10/90/100/101/20/80/10
Thoracic cavityClotted blood near to the heart0/100/100/101/10/90/100/100/20/80/10
StomachEmpty0/100/100/100/10/90/100/102/20/80/10
IntestinesEmpty0/100/100/100/10/90/100/101/20/80/10
UterusHydrometra/////1/104/101/22/84/10

Number of animals with observations/number of animals examined.
/, not examined; mg/kg bw/day, milligrams per kilogram body weight per day.