Journal of Toxicology / 2016 / Article / Tab 11

Research Article

A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

Table 11

Summary of organ weight and body weight relative to brain weight (%).

Group (mg/kg bw/d)Organ weight and body weight relative to brain weight (%)
Body weightLiverKidneysHeartThymusSpleenTestes or uterusEpididymides or ovariesAdrenalsThyroids

Males
 Control ()Mean19608.6465.49105.5452.9919.9032.71161.6475.553.581.29
SD1278.3959.628.823.844.614.5112.209.170.510.23
 180 ()Mean19285.0492.44108.8652.0718.4435.34160.2275.513.391.03
SD759.6340.098.868.623.603.0511.737.230.640.22
±%−1.763−2−78−10−5−20
SS
 300 () Mean18700.4467.55110.8756.8615.4537.96127.3164.294.040.97
SD1910.2948.0813.137.563.346.6132.036.090.640.23
±%−5057−2216−21−1513−25
SS
 375 () Mean18314.2460.80107.3460.3914.5934.7568.4155.414.521.14
SD1352.1235.167.3210.942.475.3531.265.530.450.18
±%−7−1214−276−58−2726−12
SS

Females
 Control ()Mean12466.2341.45582.69342.58321.19728.26734.1098.4734.5541.056
SD957.2837.49210.7973.7972.9175.7575.1191.8470.6520.183
 180 () Mean12062.5368.2778.9838.1418.7131.4643.107.664.201.10
SD591.8425.744.943.232.174.8312.091.390.780.23
±%−38−4−10−121126−10−84
SS
 300 () Mean12642.0356.5878.9446.3116.7130.8329.217.484.631.10
SD863.8220.884.514.302.803.608.441.660.770.23
±%14−59−219−14−1224
SS
 375 () Mean12643.1365.8079.1948.4115.8131.1729.317.694.841.13
SD1076.5140.846.376.573.625.399.331.450.850.25
±%17−414−2510−14−967
SS

±%, percent deviation versus control, mg/kg bw/d, milligrams per kilogram body weight per day; SD, standard deviation; SS, statistical significance; , number of animals.
< 0.05; < 0.01.