A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

Table 11

Summary of organ weight and body weight relative to brain weight (%).

Group (mg/kg bw/d)			Organ weight and body weight relative to brain weight (%)
		Body weight	Liver	Kidneys	Heart	Thymus	Spleen	Testes or uterus	Epididymides or ovaries	Adrenals	Thyroids
Males
Control ()	Mean	19608.6	465.49	105.54	52.99	19.90	32.71	161.64	75.55	3.58	1.29
	SD	1278.39	59.62	8.82	3.84	4.61	4.51	12.20	9.17	0.51	0.23
180 ()	Mean	19285.0	492.44	108.86	52.07	18.44	35.34	160.22	75.51	3.39	1.03
	SD	759.63	40.09	8.86	8.62	3.60	3.05	11.73	7.23	0.64	0.22
	±%	−1.7	6	3	−2	−7	8	−1	0	−5	−20
	SS
300 ()	Mean	18700.4	467.55	110.87	56.86	15.45	37.96	127.31	64.29	4.04	0.97
	SD	1910.29	48.08	13.13	7.56	3.34	6.61	32.03	6.09	0.64	0.23
	±%	−5	0	5	7	−22	16	−21	−15	13	−25
	SS
375 ()	Mean	18314.2	460.80	107.34	60.39	14.59	34.75	68.41	55.41	4.52	1.14
	SD	1352.12	35.16	7.32	10.94	2.47	5.35	31.26	5.53	0.45	0.18
	±%	−7	−1	2	14	−27	6	−58	−27	26	−12
	SS
Females
Control ()	Mean	12466.2	341.455	82.693	42.583	21.197	28.267	34.109	8.473	4.554	1.056
	SD	957.28	37.492	10.797	3.797	2.917	5.757	5.119	1.847	0.652	0.183
180 ()	Mean	12062.5	368.27	78.98	38.14	18.71	31.46	43.10	7.66	4.20	1.10
	SD	591.84	25.74	4.94	3.23	2.17	4.83	12.09	1.39	0.78	0.23
	±%	−3	8	−4	−10	−12	11	26	−10	−8	4
	SS
300 ()	Mean	12642.0	356.58	78.94	46.31	16.71	30.83	29.21	7.48	4.63	1.10
	SD	863.82	20.88	4.51	4.30	2.80	3.60	8.44	1.66	0.77	0.23
	±%	1	4	−5	9	−21	9	−14	−12	2	4
	SS
375 ()	Mean	12643.1	365.80	79.19	48.41	15.81	31.17	29.31	7.69	4.84	1.13
	SD	1076.51	40.84	6.37	6.57	3.62	5.39	9.33	1.45	0.85	0.25
	±%	1	7	−4	14	−25	10	−14	−9	6	7
	SS

±%, percent deviation versus control, mg/kg bw/d, milligrams per kilogram body weight per day; SD, standard deviation; SS, statistical significance; , number of animals.
< 0.05; < 0.01.