A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine
Table 2
Summary of notable histopathology findings.
Organs
Observations
Incidence of observations per group Dose groups (mg/kd bw/d)
Incidence of observations per group Dose groups (mg/kd bw/d)
Control
180
300
375
Control
180
300
375
Survivors
Died early
Survivors
Died early
Males
Females
Epididymides
Decreased amount of spermatozoa
0/10
0/10
1/10
1/9
1/1
/
/
/
/
/
Lack of spermatozoa
0/10
0/10
2/10
8/9
0/1
/
/
/
/
/
Testes
Decreased intensity of spermatogenesis
0/10
0/10
5/10
9/9
1/1
/
/
/
/
/
Liver
Congestion
0/10
/
/
0/9
1/1
0/10
/
/
2/2
0/10
Centrilobular necrosis
0/10
/
/
0/9
1/1
0/10
/
/
2/2
0/10
Lungs
Alveolar emphysema
2/10
/
/
1/9
1/1
2/10
/
/
2/2
2/10
Hyperplasia of BALT
2/10
/
/
1/9
0/1
1/10
/
/
0/2
0/10
Congestion
0/10
/
/
0/9
1/1
0/10
/
/
2/2
0/10
Prostate
Decreased amount of secretion
0/10
/
/
3/9
0/1
/
/
/
/
/
Skin
Exudative dermatitis
0/10
1/1
1/1
2/9
0/1
0/10
0/10
0/10
0/10
0/10
Uterus
Dilatation
/
/
/
/
/
1/10
/
/
0/2
4/9
Number of animals with observations/number of animals examined. /, not examined; BALT, bronchus associated lymphoid tissue; mg/kg bw/d, milligrams per kilogram body weight per day.
