Journal of Toxicology / 2016 / Article / Tab 2

Research Article

A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

Table 2

Summary of notable histopathology findings.

OrgansObservationsIncidence of observations per group
Dose groups (mg/kd bw/d)
Incidence of observations per group
Dose groups (mg/kd bw/d)
Control180300375Control180300375
SurvivorsDied earlySurvivorsDied early

MalesFemales
EpididymidesDecreased amount of spermatozoa0/100/101/101/91/1/////
Lack of spermatozoa0/100/102/108/90/1/////
TestesDecreased intensity of spermatogenesis0/100/105/109/91/1/////
LiverCongestion0/10//0/91/10/10//2/20/10
Centrilobular necrosis0/10//0/91/10/10//2/20/10
LungsAlveolar emphysema2/10//1/91/12/10//2/22/10
Hyperplasia of BALT2/10//1/90/11/10//0/20/10
Congestion0/10//0/91/10/10//2/20/10
ProstateDecreased amount of secretion0/10//3/90/1/////
SkinExudative dermatitis0/101/11/12/90/10/100/100/100/100/10
UterusDilatation/////1/10//0/24/9

Number of animals with observations/number of animals examined.
/, not examined; BALT, bronchus associated lymphoid tissue; mg/kg bw/d, milligrams per kilogram body weight per day.