Journal of Toxicology / 2016 / Article / Tab 3

Research Article

A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

Table 3

Summary of mean body weight gain.

Group (mg/kg bw/d)Body weight gain (g) between daysSum
0–33–77–1010–1414–1717–2121–2424–2828–3535–4242–4949–5656–6363–7070–7777–8484–890–89

Males
 Control Mean21.223.86.719.810.417.48.313.414.418.116.012.87.810.18.75.11.0215.0
SD1.83.32.93.42.43.84.23.92.93.54.02.12.33.03.93.52.415.1
 180Mean16.523.110.518.09.516.29.912.219.316.314.615.210.98.59.47.13.6220.8
SD5.23.92.53.83.83.44.73.66.23.94.74.13.34.13.13.63.722.9
SS
 300Mean10.321.67.716.98.413.210.69.816.113.314.312.19.710.611.10.94.9191.5
SD7.14.64.56.63.42.64.23.24.59.83.62.63.13.62.58.36.230.5
SS
 375Mean−1.722.710.015.910.515.39.39.411.912.112.310.97.09.810.85.27.9181.9
SD12.53.65.26.03.83.14.28.06.25.76.96.25.54.25.36.12.027.7
SS
1010101010101010101099999999

Females
 Control Mean10.913.06.99.45.27.04.46.211.66.15.96.50.75.65.73.82.2111.1
SD3.71.63.42.32.81.63.42.74.23.63.82.13.62.84.24.13.313.7
 180Mean9.113.19.08.35.78.83.68.29.75.37.57.31.14.24.54.64.0114.0
SD3.13.74.62.05.14.22.03.84.43.84.62.72.83.44.65.13.814.5
 300Mean6.714.37.88.86.79.14.58.79.68.38.04.37.22.18.12.42.4118.5
SD5.12.83.64.73.42.23.42.12.52.54.54.22.53.62.43.21.816.5
10101010101010109999988888
SS
 375Mean5.012.810.012.36.16.46.57.99.57.19.24.74.53.56.63.25.2120.5
SD2.52.73.53.34.44.44.33.35.27.65.22.42.53.95.04.53.821.4
SS

mg/kg bw/d, milligrams per kilogram body weight per day; SD, standard deviation; g, grams; SS, statistical significance; , number of animals.
< 0.05; < 0.01. unless otherwise stated.