Journal of Toxicology / 2016 / Article / Tab 4

Research Article

A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

Table 4

Summary of mean body weight.

Group (mg/kg bw/d)Body weight (g) on days
037101417212428354249566370778489

Males
 Control Mean218.6239.8263.6270.3290.1300.5317.9326.2339.6354.0372.1388.1400.9408.7418.8427.5432.6433.6
SD7.27.910.011.212.913.916.815.616.817.018.219.518.818.418.818.119.718.9
101010101010101010101010101010101010
 180Mean218.3234.8257.9268.4286.4295.9312.1322.0334.2353.5369.8384.4399.6410.5419.0428.4435.5439.1
SD7.210.912.012.215.517.515.716.015.918.419.421.721.522.123.824.026.126.2
±%0−2−2−1−1−2−2−1−20−1−1000011
101010101010101010101010101010101010
 300 Mean217.2227.5249.1256.8273.7282.1295.3305.9315.7331.8345.1359.4371.5381.2391.8402.9403.8408.7
SD6.29.312.012.514.814.814.816.916.918.023.925.225.526.027.027.328.631.7
±%−1−5−6−5−6−6−7−6−7−6−7−7−7−7−6−6−7−6
SS
101010101010101010101010101010101010
 375 Mean217.1215.4238.1248.1264.0274.5289.8299.1308.5320.4332.5348.2359.1366.1375.9386.7391.9399.8
SD5.513.412.011.013.314.314.815.917.116.418.316.720.022.923.725.128.228.4
±%−1−10−10−8−9−9−9−8−9−9−11−10−10−10−10−10−9−8
SS
10101010101010101010109999999

Females
 Control Mean139.8150.7163.7170.6180.0185.2192.2196.6202.8214.4220.5226.4232.9233.6239.2244.9248.7250.9
SD5.56.77.48.810.211.112.011.513.012.013.413.814.314.214.216.215.517.2
101010101010101010101010101010101010
 180 Mean140.1149.2162.3171.3179.6185.3194.1197.7205.9215.6220.9228.4235.7236.8241.0245.5250.1254.1
SD5.96.14.55.04.86.38.28.49.711.411.913.314.013.914.014.015.615.8
±%0−1−1000112101111011
101010101010101010101010101010101010
 300 Mean139.4146.1160.4168.2177.0183.7192.8197.3206.0216.4224.8232.8237.1244.3245.4253.5255.9258.3
SD2.04.44.65.87.37.28.49.99.810.811.413.314.513.415.515.716.117.1
±%0−3−2−1−2−1002123253433
101010101010101010999998888
 375 Mean141.0146.0158.8168.8181.1187.2193.6200.1208.0217.5224.6233.8238.5243.0246.5253.1256.3261.5
SD5.26.16.97.68.87.910.511.711.215.916.816.216.516.019.121.121.523.4
±%1−3−3−111123123243334
101010101010101010101010101010101010

±%, percent deviation versus control; mg/kg bw/d, milligrams per kilogram body weight per day; SD, standard deviation; g, grams; SS, statistical significance; , number of animals.
< 0.05; < 0.01.