Journal of Toxicology / 2016 / Article / Tab 8

Research Article

A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

Table 8

Summary of statistically significant clinical chemistry findings.

Dose group (mg/kg bw/d)
⁢Males⁢Females
Control 
180  
300 
375 
Historical rangeControl 
180 
300 
375  
Historical range

ALT (U/L)54.97 ± 10.6266.51 ± 7.2973.55 ± 13.8175.58 ± 18.0938.5–98.058.26 ± 11.8868.12 ± 12.1473.925 ± 17.2378.25 ± 14.9131.4–84.1
AST (U/L)94.64 ± 20.70101.81 ± 12.7598.25 ± 8.76112.53 ± 17.9072.6–123.595.25 ± 16.8289.75 ± 16.2099.39 ± 17.46112.36 ± 20.0075.0–116.6
ALP (U/L)102.80 ± 20.4778.8 ± 10.8979.70 ± 12.2889.44 ± 25.6767–21555.9 ± 17.2572.90 ± 25.8860.88 ± 35.4573.40 ± 32.0020–185
TBIL (μmol/L)1.71 ± 0.231.69 ± 0.282.07 ± 0.372.09 ± 0.350.62–4.721.839 ± 0.451.44 ± 0.341.86 ± 0.381.85 ± 0.620.91–4.69
CREA (μmol/L)28.70 ± 2.7332.76 ± 3.9734.35 ± 4.5835.97 ± 2.8923.1–37.029.3 ± 2.3229.51 ± 3.2830.30 ± 3.5531.15 ± 3.0625.9–38.2
Urea (μmol/L)7.48 ± 0.917.20 ± 0.887.64 ± 0.867.64 ± 0.824.14–9.626.947 ± 0.717.19 ± 1.046.83 ± 0.857.08 ± 0.824.79–9.71
GLUC (μmol/L)6.04 ± 0.525.99 ± 0.535.62 ± 0.435.35 ± 0.334.98–7.975.73 ± 0.495.71 ± 0.495.10 ± 0.804.53 ± 0.414.18–8.49
Pi (μmol/L)1.90 ± 0.282.09 ± 0.252.09 ± 0.202.39 ± 0.241.40–2.061.275 ± 0.161.53 ± 0.162.12 ± 0.202.11 ± 0.391.3–2.1
Ca (μmol/L)2.67 ± 0.082.58 ± 0.112.56 ± 0.092.63 ± 0.072.39–2.752.617 ± 0.062.55 ± 0.102.57 ± 0.072.54 ± 0.102.4–2.8
Na (μmol/L)142.00 ± 1.05140.00 ± 1.49138.80 ± 1.14138.67 ± 0.87137–147140.6 ± 0.97139.90 ± 1.79139.25 ± 1.58138.50 ± 2.51137–147
K (μmol/L)4.41 ± 0.254.61 ± 0.394.23 ± 0.154.45 ± 0.263.62–5.313.921 ± 0.244.15 ± 0.214.28 ± 0.324.24 ± 0.453.6–4.4
Cl (μmol/L)105.65 ± 0.98103.4 ± 1.70102.24 ± 0.98102.46 ± 1.34101.0–106.6104.66 ± 0.74103.56 ± 1.37102.79 ± 1.15102.79 ± 2.22101.2–109.6
ALB (g/L)34.21 ± 0.7233.08 ± 0.8832.03 ± 1.6133.63 ± 1.1931.5–36.735.77 ± 1.2934.73 ± 1.1034.76 ± 1.4535.03 ± 2.0432.9–41.1
TPROT (g/L)62.59 ± 3.3059.7 ± 2.4457.37 ± 2.3061.22 ± 2.7055.5–70.664.76 ± 3.5362.09 ± 2.6062.65 ± 2.6664.29 ± 5.1757.6–79.3

Values are expressed as mean ± standard deviation. Historical Range based on data from 40 male and 38 female (19 females for BUN and Pi) Hsd.Brl.Han Wistar control rats aged 19-20 weeks.
mg/kg bw/d, milligrams per kilogram body weight per day; U/L, units per liter; μmol, micromol; g, gram; , number of animals.
< 0.05; < 0.01.