Chalcone Scaffold in Anticancer Armamentarium: A Molecular Insight

<div>Chalcones against cervix adenocarcinoma cell lines. ((<b>10a</b>) to (<b>10c</b>)) IC<sub>50</sub> values ranging from 2.36 to 2.73 <i>μ</i>M: increases p18 Bax, accumulation of cells in S, and G<sub>2</sub>/M phases. (<b>11</b>) IC<sub>50</sub> of 4.7 to 7.6 <i>μ</i>M: induction of caspase-dependent intrinsic pathway p53 and its transcriptional target PUMA upregulation.</div>

Journal of Toxicology

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Figure 5

Figure 5: Chalcone Scaffold in Anticancer Armamentarium: A Molecular Insight 