Chalcone Scaffold in Anticancer Armamentarium: A Molecular Insight

Figure 7

Chalcones against hepatocellular carcinoma cell lines. (20) IC₅₀ of 6.25  μM: mitochondria dependent pathway involving inhibition of Bcl-2 expression leading to disintegration of the outer mitochondrial membrane. Caspase-3 and caspase-9 activities. (21) IC₅₀ of 10 μM: hypoxia inducible factor-1 (HIF-1) inhibitor.