Chalcone Scaffold in Anticancer Armamentarium: A Molecular Insight

Figure 8

Chalcones against bladder and prostate cancer cell lines. (22) Concentration of 6 μg/mL: reduction in the expression of cyclin A and cyclin B1, decrease in the expression of Cdc2 and an increase in the expression of p21 and p27, increase in the expression of proapoptotic proteins Bax and Bak, and decrease in the expression of antiapoptotic proteins Bcl-2, Bcl-xL proteins; NF-κB activation by increasing the expression of IκBα in cytoplasm leads to apoptosis. (23) IC₅₀ value of 5.95 μM: copper ions might act as penetration enhancers of chalcones into cancer cells and might act as inhibitors of drug efflux proteins.