Evaluating the Effects of Tetrachloro-1,4-benzoquinone, an Active Metabolite of Pentachlorophenol, on the Growth of Human Breast Cancer Cells

<div>Apoptotic (caspase 3/7 level) effect of TCBQ towards human breast cancer MCF7 (a), Sk-Br-3 (b), and MDA-MB-231 (c) cells. The concentration of TCBQ was 0.16 µM, 0.31 µM, 0.63 µM, 1.25 µM, 2.5 µM, 5 µM, and 10 µM, respectively. Treatment with DMSO was used as negative control. Apoptosis was increased upon TCBQ treatment towards the MCF7 cells. The increase of apoptosis (%) compared to control was statistically significant at all TCBQ concentrations. However, apoptosis was decreased upon TCBQ treatment against the Sk-Br-3 and MDA-MB-231 cells. The decrease of apoptosis (%) compared to control was statistically insignificant at all TCBQ concentrations towards both cell lines. Statistical analysis was performed by one-way ANOVA with Dunnett’s comparison as posthoc analysis.</div>

Journal of Toxicology

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Figure 3: Evaluating the Effects of Tetrachloro-1,4-benzoquinone, an Active Metabolite of Pentachlorophenol, on the Growth of Human Breast Cancer Cells 

Figure 3 | Evaluating the Effects of Tetrachloro-1,4-benzoquinone, an Active Metabolite of Pentachlorophenol, on the Growth of Human Breast Cancer Cells 