Table of Contents Author Guidelines Submit a Manuscript
Journal of Toxicology
Volume 2016, Article ID 8606410, 7 pages
http://dx.doi.org/10.1155/2016/8606410
Research Article

Neurotoxic Effect of Benzo[a]pyrene and Its Possible Association with 6-Hydroxydopamine Induced Neurobehavioral Changes during Early Adolescence Period in Rats

1Department of Zoology, School of Life Sciences, Ravenshaw University, Cuttack, Odisha 753003, India
2Department of High Altitude Physiology, Defence Institute of High Altitude Research, Leh 901205, India

Received 30 September 2015; Revised 9 February 2016; Accepted 11 February 2016

Academic Editor: Maria Teresa Colomina

Copyright © 2016 Saroj Kumar Das et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. L. Jacobson and S. W. Jacobson, “Intellectual impairment in children exposed to polychlorinated biphenyls in utero,” The New England Journal of Medicine, vol. 335, no. 11, pp. 783–789, 1996. View at Publisher · View at Google Scholar · View at Scopus
  2. S. J. Barone, K. P. Das, T. L. Lassiter, and L. D. White, “Vulnerable processes of nervous system development: a review of markers and methods,” NeuroToxicology, vol. 21, no. 1-2, pp. 15–36, 2000. View at Google Scholar · View at Scopus
  3. C. R. Saunders, S. K. Das, A. Ramesh, D. C. Shockley, and S. Mukherjee, “Benzo(a)pyrene-induced acute neurotoxicity in the F-344 rat: role of oxidative stress,” Journal of Applied Toxicology, vol. 26, no. 5, pp. 427–438, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Chen, Y. Tang, X. Jiang et al., “Early postnatal benzo(a)pyrene exposure in sprague-dawley rats causes persistent neurobehavioral impairments that emerge postnatally and continue into adolescence and adulthood,” Toxicological Sciences, vol. 125, no. 1, Article ID kfr265, pp. 248–261, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. É. S. Maciel, R. Biasibetti, A. P. Costa et al., “Subchronic oral administration of Benzo[a]pyrene impairs motor and cognitive behavior and modulates S100B levels and MAPKs in rats,” Neurochemical Research, vol. 39, no. 4, pp. 731–740, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. C. R. Saunders, D. C. Shockley, and M. E. Knuckles, “Behavioral effects induced by acute exposure to benzo(a) pyrene in F-344 rats,” Neurotoxicity Research, vol. 3, no. 6, pp. 557–579, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. C. R. Saunders, A. Ramesh, and D. C. Shockley, “Modulation of neurotoxic behavior in F-344 rats by temporal disposition of benzo(a)pyrene,” Toxicology Letters, vol. 129, no. 1-2, pp. 33–45, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Andersson, E. Lindqvist, R. Westerholm, K. Grägg, J. Almén, and L. Olson, “Neurotoxic effects of fractionated diesel exhausts following microinjections in rat hippocampus and striatum,” Environmental Research, vol. 76, no. 1, pp. 41–51, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Cordier, B. Lefeuvre, G. Filippini et al., “Parental occupation, occupational exposure to solvents and polycyclic aromatic hydrocarbons and risk of childhood brain tumors (Italy, France, Spain),” Cancer Causes and Control, vol. 8, no. 5, pp. 688–697, 1997. View at Publisher · View at Google Scholar · View at Scopus
  10. F. P. Perera, V. Rauh, W.-Y. Tsai et al., “Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population,” Environmental Health Perspectives, vol. 111, no. 2, pp. 201–205, 2003. View at Google Scholar · View at Scopus
  11. M. J. Zigmond and E. M. Stricker, “Animal models of parkinsonism using selective neurotoxins: clinical and basic implications,” International Review of Neurobiology, vol. 31, pp. 1–79, 1989. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Gerlach and P. Riederer, “Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man,” Journal of Neural Transmission, vol. 103, no. 8-9, pp. 987–1041, 1996. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Iancu, P. Mohapel, P. Brundin, and G. Paul, “Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice,” Behavioural Brain Research, vol. 162, no. 1, pp. 1–10, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. B. A. Shaywitz, R. D. Yager, and J. H. Klopper, “Selective brain dopamine depletion in developing rats: an experimental model of minimal brain dysfunction,” Science, vol. 191, no. 4224, pp. 305–308, 1976. View at Publisher · View at Google Scholar · View at Scopus
  15. O. T. Korkmaz, H. Ay, E. Ulupinar, and N. Tunçel, “Vasoactive intestinal peptide enhances striatal plasticity and prevents dopaminergic cell loss in Parkinsonian rats,” Journal of Molecular Neuroscience, vol. 48, no. 3, pp. 565–573, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. S. K. Das, I. Baitharu, K. Barhwal, S. K. Hota, and S. B. Singh, “Early mood behavioral changes following exposure to monotonous environment during isolation stress is associated with altered hippocampal synaptic plasticity in male rats,” Neuroscience Letters, vol. 612, pp. 231–237, 2016. View at Publisher · View at Google Scholar
  17. H. Khoshbouei, M. Cecchi, and D. A. Morilak, “Amplication of the noradrenergic response to stress elicits galanin-mediated anxiolytic effects in central amygdala,” Pharmacology, Biochemistry & Behavior, vol. 71, no. 3, pp. 407–417, 2002. View at Google Scholar
  18. S. K. Das, K. Barhwal, S. K. Hota, M. K. Thakur, and R. B. Srivastava, “Disrupting monotony during social isolation stress prevents early development of anxiety and depression like traits in male rats,” BMC Neuroscience, vol. 16, article 2, 2015. View at Publisher · View at Google Scholar
  19. P. Stephanou, M. Konstandi, P. Pappas, and M. Marselos, “Alterations in central monoaminergic neurotrasmission induced by polycyclic aromatic hydrocarbons in rats,” European Journal of Drug Metabolism and Pharmacokinetics, vol. 23, no. 4, pp. 475–481, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Davenport, G. Camougis, and J. F. Hickok, “Analyses of the behaviour of commensals in host-factor. 1. A hesioned polychaete and a pinnotherid crab,” Animal Behaviour, vol. 8, no. 3-4, pp. 209–218, 1960. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Motelay-Massei, D. Ollivon, B. Garban, K. Tiphagne-Larcher, I. Zimmerlin, and M. Chevreuil, “PAHs in the bulk atmospheric deposition of the Seine river basin: source identification and apportionment by ratios, multivariate statistical techniques and scanning electron microscopy,” Chemosphere, vol. 67, no. 2, pp. 312–321, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Patri, A. Singh, and B. N. Mallick, “Protective role of noradrenaline in benzo[a]pyrene-induced learning impairment in developing rat,” Journal of Neuroscience Research, vol. 91, no. 11, pp. 1450–1462, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. D. R. Davila, D. L. Romero, and S. W. Burchiel, “Human T cells are highly sensitive to suppression of mitogenesis by polycyclic aromatic hydrocarbons and this effect is differentially reversed by α-naphthoflavone,” Toxicology and Applied Pharmacology, vol. 139, no. 2, pp. 333–341, 1996. View at Publisher · View at Google Scholar · View at Scopus
  24. B. Weiss, “Vulnerability of children and the developing brain to neurotoxic hazards,” Environmental Health Perspectives, vol. 108, no. 3, pp. 375–381, 2000. View at Google Scholar · View at Scopus
  25. B. Kolb and I. Q. Whishaw, “Plasticity in the neocortex: mechanisms underlying recovery from early brain damage,” Progress in Neurobiology, vol. 32, no. 4, pp. 235–276, 1989. View at Publisher · View at Google Scholar · View at Scopus
  26. L.-G. Chia, D.-R. Ni, L.-J. Cheng, J.-S. Kuo, F.-C. Cheng, and G. Dryhurst, “Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 5,7-dihydroxytryptamine on the locomotor activity and striatal amines in C57BL/6 mice,” Neuroscience Letters, vol. 218, no. 1, pp. 67–71, 1996. View at Publisher · View at Google Scholar · View at Scopus
  27. E. Rousselet, C. Joubert, J. Callebert et al., “Behavioral changes are not directly related to striatal monoamine levels, number of nigral neurons, or dose of Parkinsonian toxin MPTP in mice,” Neurobiology of Disease, vol. 14, no. 2, pp. 218–228, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Bouayed, F. Desor, H. Rammal et al., “Effects of lactational exposure to benzo[α]pyrene (B[α]P) on postnatal neurodevelopment, neuronal receptor gene expression and behaviour in mice,” Toxicology, vol. 259, no. 3, pp. 97–106, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. D. Blum, S. Torch, N. Lambeng et al., “Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease,” Progress in Neurobiology, vol. 65, no. 2, pp. 135–172, 2001. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Masuo, M. Ishido, M. Morita, S. Oka, and E. Niki, “Motor activity and gene expression in rats with neonatal 6-hydroxydopamine lesions,” Journal of Neurochemistry, vol. 91, no. 1, pp. 9–19, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. A. B. Richards, T. A. Scheel, K. Wang, M. Henkemeyer, and L. F. Kromer, “EphB1 null mice exhibit neuronal loss in substantia nigra pars reticulata and spontaneous locomotor hyperactivity,” European Journal of Neuroscience, vol. 25, no. 9, pp. 2619–2628, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Grealish, L. Xie, M. Kelly, and E. Dowd, “Unilateral axonal or terminal injection of 6-hydroxydopamine causes rapid-onset nigrostriatal degeneration and contralateral motor impairments in the rat,” Brain Research Bulletin, vol. 77, no. 5, pp. 312–319, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. V. Gaur, S. L. Bodhankar, V. Mohan, and P. A. Thakurdesai, “Neurobehavioral assessment of hydroalcoholic extract of Trigonella foenum-graecum seeds in rodent models of Parkinson's disease,” Pharmaceutical Biology, vol. 51, no. 5, pp. 550–557, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Zhang, X.-H. Gui, L.-P. Huang et al., “Neuroprotective effects of β-asarone against 6-hydroxy dopamine-induced parkinsonism via JNK/Bcl-2/beclin-1 pathway,” Molecular Neurobiology, vol. 53, no. 1, pp. 83–94, 2016. View at Publisher · View at Google Scholar · View at Scopus
  35. M. V. Mabandla, M. Nyoka, and W. M. Daniels, “Early use of oleanolic acid provides protection against 6-hydroxydopamine induced dopamine neurodegeneration,” Brain Research, vol. 1622, pp. 64–71, 2015. View at Publisher · View at Google Scholar