Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in Rats

Table 1

Effect of DLD (25 mg/kg/day) and DHD (50 mg/kg/day) on serum creatinine, serum urea, MDA, and levels in DOX -induced nephrotoxicity (15 mg/kg).

Group	Creatinine (mg/dL)	Urea (mg/dL)	MDA (nmol/g tissue)	(nmol/g tissue)
Control	0.8828 ± 0.07291	50.26 ± 4.450	42.27 ± 2.202	179.5 ± 11.98
DLD	0.7395 ± 0.06486	51.75 ± 1.721	44.77 ± 2.098	272.8 ± 22.35
DHD	0.9540 ± 0.08678	53.73 ± 2.989	52.02 ± 5.036	295.0 ± 20.25
DOX	1.475 ± 0.0522^a	251.8 ± 12.23^a	250.9 ± 16.37^a	1114 ± 64.29^a
DOX/DLD	1.211 ± 0.0660^ab	241.7 ± 13.17^a	51.86 ± 4.461^b	322.8 ± 11.33^ab
DOX/DHD	1.153 ± 0.0209^ab	69.74 ± 4.161^b	46.79 ± 1.39^b	228.5 ± 18.83^b

Values are representation of 4–6 observations as means ± SEM. Results are considered significantly different when . Significant difference compared to control; significant difference compared to DOX group.