Comparative Hepatotoxicity of Fluconazole, Ketoconazole, Itraconazole, Terbinafine, and Griseofulvin in Rats

Table 1

Effect of the five oral antifungal agents (griseofulvin, fluconazole, ketoconazole, itraconazole, and terbinafine) on serum activities of AST, ALT, and ALP in rats after 14 days of treatment.

Groups	AST/IU mean ± SEM	ALT/IU mean ± SEM	ALP/IU mean ± SEM
Control	58.50 ± 5.40	60.17 ± 6.30	152.17 ± 5.57
Griseofulvin	124.33 ± 25.17	86.33 ± 8.06	370.50 ± 19.81
Fluconazole	275.83 ± 69.45	178.33 ± 42.85	409.50 ± 29.78
Ketoconazole	431.17 ± 101.89	283.17 ± 61.96	324.67 ± 18.33
Itraconazole	272.00 ± 48.10	172.17 ± 44.18	414.50 ± 17.19
Terbinafine	135.67 ± 34.98	88.67 ± 6.10	420.33 ± 26.30

AST: aspartate aminotransferase, ALT: alanine aminotransferase, and ALP: alkaline phosphatase
Tukey’s post hoc analysis: like letters (a–e) indicate nonsignificant differences.