Tramadol Induced Adrenal Insufficiency: Histological, Immunohistochemical, Ultrastructural, and Biochemical Genetic Experimental Study

Figure 12

(a) Electron micrographs of zona fasciculata cells of group II showing vacuoles of variable sizes (V), mitochondria with destroyed cristae (M), lipid droplets without discernible outline (L), and a shrunken hyperchromatic nucleus with an irregular outline (N). Note confluent lipid droplets (star). (b) Another cell has an irregular nucleus (N) with dilated perinuclear space (arrow), mitochondria with destroyed cristae (M), and numerous dilated profiles of smooth endoplasmic reticulum (s). Notice cytoplasmic vacuoles with electron-dense cores (circles).

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