Protective Effect of Phaleria macrocarpa Water Extract (Proliverenol) against Carbon Tetrachloride-Induced Liver Fibrosis in Rats: Role of TNF-α and TGF-β1

Figure 2

(a) The liver histopathological examination samples stained by Masson’s trichrome (400x). Blue color showed collagen deposition around portal triad. A: normal group. B: CCl₄ group. C: CCl₄+NAC group. D: CCl₄+T50 group. E: CCl₄+T100 group. F: CCl₄+T150 group. N: normal, CCl₄: carbon tetrachloride, NAC: N-acetylcysteine 150 mg/kg body weight/day, and T50, T100, and T150: DLBS Proliverenol 50, 100, and 150 mg/kg body weight/day. (b) Fibrosis percentage of normal control, CCl₄, CCl₄₊NAC150, CCl₄₊T50, CCl₄₊T100, and CCl₄₊T150 groups. Data represent the means ± SD (n=5). N: normal, CCl₄: carbon tetrachloride, NAC: N-acetylcysteine 150 mg/kg body weight/day, and T50, T100, and T150: Proliverenol 50, 100, and 150 mg/kg body weight/day. A = p < 0.05 vs. N, B = p < 0.05 vs. CCl₄ (α=0.05).

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