Synergistic Effect of Quercetin and α-Lipoic Acid on Aluminium Chloride Induced Neurotoxicity in Rats

Table 1

Effect of aluminum chloride, quercetin, and α-lipoic acid (ALA) treatment on oxidative stress indices in rat brain.

Experimental groups	Lipid peroxidation	Protein carbonyl
Control	4.21 ± 0.61	34.0 ± 2.39
Aluminum chloride	14.4 ± 0.2	74.6 ± 4.98
Quercetin	3.7 ± 0.21	29.4 ± 1.25
Quercetin + aluminum chloride	4.72 ± 0.26	38.5 ± 2.37
α-Lipoic acid	3.67 ± 0.249	29.8 ± 1.17
α-Lipoic acid + aluminum chloride	4.77 ± 0.272	38.2 ± 1.59
Quercetin + α-lipoic acid	3.58 ± 0.23	29.69 ± 2.32
Quercetin + α-lipoic acid + aluminum chloride	4.14 ± 0.07	32.7 ± 1.81

Values are expressed as ± nmoles × 10⁻⁷ of MDA formed/min/mg protein; values are expressed as ±  M protein carbonyl/mg protein; significant as compared to control group of rats (); significant as compared to control group of rats (); nonsignificant as compared to control (); significant as when compared to AlCl₃ (); comparison between the groups was done using Dunnett’s multiple comparison test.