Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberration in Onion Root Cells

Table 8

Normal mitotic activity and chromosome behavior can be recovered after short-term exposure to DHAP.

Duration of exposure	Recovery time in water	Mitotic index (%)				Chromosome aberrations (%)
		Control	0.25μg/ml	0.5μg/ml	1.0μg/ml
0hr	0hr	5.90	-	-	-	-
3hrs	12hrs	-	3.75	2.27	2.24	4.53
	24hrs	-	5.57	2.94	3.02	5.30
	48hrs	-	6.51	5.41	4.80	1.05
6hrs	24hrs	-	5.32	3.24	3.00	5.35
	44hrs	-	4.21	2.98	1.98	6.82
48hrs	0hr	-	3.48	2.74	1.44	16.9

Data was analysed with regular two-way ANOVA. Data is significant different based on duration of exposure (P<0.0001) and concentrations of DHAP (P<0.001).