Research Article

A Toxicological Evaluation of a Standardized Hydrogenated Extract of Curcumin (CuroWhite™)

Table 4

Summary of the results of Method II (preincubation test).

Test concentration
(/plate)
Number of revertants/plate (mean of 3 plates)
Without S9-mixWith S9-mix

TA 98TA 100WP2 uvrATA 1535TA 1537TA 98TA 100WP2 uvrATA 1535TA 1537

Historical negative control range20–5045–20010–505–205–2020–5045–20010–505–205–20
Solvent control (DMSO)
(0.1 ml)
Mean2068431112176532109
SD4334325332
0.062 mgMean24624210720603297
SD2222242223
0.185 mgMean2876441581981401311
SD3242331242
0.556 mgMean25814015152576331314
SD3841114532
1.667 mgMean23834414152578341412
SD5334441333
2.5 gMean23784316142674311216
SD6234353233
3.75 mgMean29864213132878321312
SD3322234233
5 mgMean33803514172582331314
SD4444213532
2-NitrofluoreneSodium azide4-NitroquinolineSodium azide9-Aminoacridine2-Aminoanthracene

Positive controlsMean390478134206229382470131231219
SD26212044302721201428

DMSO: dimethylsulfoxide; SD: standard deviation; TA: Salmonella Typhimurium tester strains; WP2 uvrA: Escherichia coli tester strain. Notes. All values are expressed as mean revertant colonies per plate ± standard deviation.