A Toxicological Evaluation of a Standardized Hydrogenated Extract of Curcumin (CuroWhite™)
Table 4
Summary of the results of Method II (preincubation test).
Test concentration (/plate)
Number of revertants/plate (mean of 3 plates)
Without S9-mix
With S9-mix
TA 98
TA 100
WP2 uvrA
TA 1535
TA 1537
TA 98
TA 100
WP2 uvrA
TA 1535
TA 1537
Historical negative control range
20–50
45–200
10–50
5–20
5–20
20–50
45–200
10–50
5–20
5–20
Solvent control (DMSO) (0.1 ml)
Mean
20
68
43
11
12
17
65
32
10
9
SD
4
3
3
4
3
2
5
3
3
2
0.062 mg
Mean
24
62
42
10
7
20
60
32
9
7
SD
2
2
2
2
2
4
2
2
2
3
0.185 mg
Mean
28
76
44
15
8
19
81
40
13
11
SD
3
2
4
2
3
3
1
2
4
2
0.556 mg
Mean
25
81
40
15
15
25
76
33
13
14
SD
3
8
4
1
1
1
4
5
3
2
1.667 mg
Mean
23
83
44
14
15
25
78
34
14
12
SD
5
3
3
4
4
4
1
3
3
3
2.5 g
Mean
23
78
43
16
14
26
74
31
12
16
SD
6
2
3
4
3
5
3
2
3
3
3.75 mg
Mean
29
86
42
13
13
28
78
32
13
12
SD
3
3
2
2
2
3
4
2
3
3
5 mg
Mean
33
80
35
14
17
25
82
33
13
14
SD
4
4
4
4
2
1
3
5
3
2
2-Nitrofluorene
Sodium azide
4-Nitroquinoline
Sodium azide
9-Aminoacridine
2-Aminoanthracene
Positive controls
Mean
390
478
134
206
229
382
470
131
231
219
SD
26
21
20
44
30
27
21
20
14
28
DMSO: dimethylsulfoxide; SD: standard deviation; TA: Salmonella Typhimurium tester strains; WP2 uvrA: Escherichia coli tester strain. Notes. All values are expressed as mean revertant colonies per plate ± standard deviation.