A Toxicological Evaluation of a Standardized Hydrogenated Extract of Curcumin (CuroWhite™)

Table 9

Summary of histopathological findings.

Group (mg/kg bw/day)	G1-control; ()	G4-800; ()	G4R-800; ()
Organs and observations, male
Multiple organs: autolytic changes	0/10	1/10^†	/
Liver: MNC infiltration	5/10	2/10	/
Kidneys: MNC infiltration	5/10	1/10	/
Lungs: MNC infiltration, perivascular	2/10	1/10	/
Lungs: bronchopneumonia, congestion, alveolar edema	0/10	1/10^†	/
Salivary glands: MNC infiltration	2/10	0/10	/
Spinal cord: MNC infiltration	1/10	1/10	/
Epididymis: MNC infiltration	1/10	0/10	/
Eyes: periorbital inflammation	1/10	1/10	/
Urinary bladder: MNC infiltration	0/10	1/10	/
Organs and observations, female
Multiple organs: autolytic changes	0/10	0/10	1/1^‡
Liver: MNC infiltration	5/10	2/10	0/1
Kidneys: MNC infiltration	5/10	2/10	0/1
Lungs: MNC infiltration, perivascular	5/10	3/10	0/1
Lungs: congestion, alveolar edema	0/10	0/10	1/1^‡
Thymus: epithelial cyst	1/10	0/10	0/1

MNC: mononuclear cell. Symbols.  Not examined. Animal number 31 was found dead on Day 63. Animal number 99 was found dead on Day 62. Notes. Data represent the incidence of the observation (number of animals with observation per number of animals observed).