An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin
Table 11
Summary of coagulation parameters for the 90-day study on curcumin.
Group n=20
PT
APTT
Fibrinogen
mg/kg bw/day
(Sec)
(Sec)
(mg/dl)
Males
Vehicle 0
Mean
17.42
16.53
431.05
SD
3.34
5.86
117.12
250
Mean
17.29
19.03
336.03-
SD
5.08
5.16
70.20
500
Mean
14.84-
14.67
407.63
SD
1.99
3.13
55.83
1000
Mean
14.84-↓
13.73
355.00-
SD
1.64
2.37
62.36
Reference Item 1000
Mean
16.30
13.48-
392.72
SD
1.91
4.35
57.90
Historical Range
14.90–21.00
10.00–19.60
145.30–985.40
Females
Vehicle 0
Mean
15.08
16.32
268.18
SD
0.75
2.83
63.57
250
Mean
18.45+
14.47
264.64
SD
1.34
3.19
188.79
500
Mean
17.55+
12.72-
241.01
SD
2.51
2.38
50.99
1000
Mean
14.83↓
17.97
324.30
SD
0.66
3.50
263.26
Reference Item 1000
Mean
19.20+
16.87
246.29
SD
1.69
3.71
44.00
Historical Range
14.50–21.90
7.40–21.00
243.50–758.10
N= number of animals, = statistically significant increase/decrease as compared to vehicle control (p<0.05), = statistically significant increase/decrease as compared to vehicle control (p<0.01), and ↓ = statistically significant decrease as compared to the reference item group (p<0.05). APTT, activated partial thromboplastin time; PT, prothrombin time.
