An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin
Table 13
Summary of absolute organ weights for 90-day study on curcumin.
Group
Absolute Organ Weights (g)
n=20 mg/kg bw/d
Adrenal glands
Heart
Brain
Liver
Kidneys
Spleen
Testes/Ovaries
Epididymides/Uterus
Males
Vehicle
Mean
0.056
1.028
2.104
10.577
2.293
0.665
3.661
1.451
0
SD
0.007
0.070
0.119
1.290
0.252
0.082
0.366
0.141
250
Mean
0.059
1.028
2.174
10.378
2.332
0.614
3.776
1.497
SD
0.007
0.080
0.090
1.118
0.247
0.104
0.218
0.103
500
Mean
0.062
1.101+
2.222+
11.452
2.605+
0.723
3.898+
1.546+
SD
0.007
0.097
0.124
0.874
0.578
0.140
0.492
0.134
1000
Mean
0.056
1.049
2.126
11.217
2.398
0.665
3.736
1.516
SD
0.011
0.079
0.161
1.263
0.176
0.106
0.416
0.117
Ref Item
Mean
0.060
1.005
2.110
10.904
2.334
0.608-
3.755
1.498
1000
SD
0.010
0.082
0.132
1.064
0.186
0.137
0.257
0.103
Females
Vehicle
Mean
0.071
0.751
2.044
6.662
1.805
0.445
0.171
0.696
0
SD
0.008
0.066
0.068
0.705
1.186
0.049
0.032
0.177
250
Mean
0.072
0.668
2.010
6.536
1.506
0.500
0.163
0.593
SD
0.009
0.207
0.121
0.591
0.103
0.098
0.015
0.101
500
Mean
0.070
0.729
2.036
6.263-
1.498
0.457
0.173
0.625
SD
0.012
0.079
0.119
0.664
0.152
0.065
0.022
0.109
1000
Mean
0.077+
0.779
2.091
7.074
1.607
0.474
0.179
0.637
SD
0.011
0.054
0.116
0.681
0.154
0.056
0.031
0.159
Ref Item
Mean
0.078
0.764
2.066
7.023
1.541
0.481
0.178
0.710
1000
SD
0.016
0.076
0.132
0.950
0.173
0.077
0.038
0.223
N= number of animals; = statistically significant increase/decrease as compared to vehicle control (p<0.05); = statistically significant increase/decrease as compared to vehicle control (p<0.01); Ref, reference.
