An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin
Table 14
Summary of relative organ weights (organ:body) for the 90-day study on curcumin.
Group / Dose (mg/kg b.w./day)
Fasted B. wt. (g)
Relative Organ Weights (%)
n=20
Adrenal glands
Heart
Brain
Lungs
Liver
Kidneys
Spleen
Thymus
Testes/Ovaries
Epididymides/Uterus
Males
Vehicle
Mean
380.079
0.015
0.272
0.557
0.506
2.783
0.604
0.176
0.100
0.969
0.383
0
SD
36.908
0.002
0.025
0.048
0.096
0.201
0.039
0.027
0.029
0.107
0.031
250
Mean
365.490
0.016
0.283
0.599
0.529
2.843
0.640+
0.167
0.104
1.039
0.412
SD
34.259
0.002
0.028
0.048
0.114
0.205
0.055
0.020
0.024
0.089
0.038
500
Mean
394.160
0.016
0.280
0.566
0.571
2.913
0.661+
0.184
0.097
0.993
0.393
SD
28.692
0.002
0.023
0.048
0.161
0.222
0.135
0.033
0.020
0.139
0.033
1000
Mean
380.596
0.015
0.276
0.560
0.471
2.946+
0.631
0.175
0.103
0.982
0.399
SD
25.771
0.003
0.022
0.038
0.106
0.267
0.043
0.024
0.022
0.092
0.029
Reference
Mean
364.692
0.016
0.277
0.583
0.549
3.003+
0.643+
0.167
0.101
1.035
0.413
Item 1000
SD
34.131
0.003
0.022
0.063
0.160
0.305
0.051
0.036
0.022
0.091
0.039
Females
0
Mean
222.861
0.032
0.337
0.922
0.656
2.988
0.810
0.200
0.148
0.077
0.315
SD
16.701
0.003
0.021
0.072
0.147
0.215
0.527
0.025
0.022
0.013
0.089
250
Mean
216.313
0.033
0.311
0.932
0.777+
3.029
0.697
0.231+
0.158
0.076
0.275
SD
14.168
0.004
0.098
0.069
0.218
0.286
0.041
0.039
0.022
0.009
0.050
500
Mean
213.676
0.033
0.341
0.956
0.699
2.931
0.701
0.214
0.158
0.081
0.294
SD
15.403
0.006
0.028
0.067
0.147
0.226
0.046
0.027
0.032
0.012
0.055
1000
Mean
228.603
0.034
0.342
0.920
0.762
3.100
0.705
0.208
0.151
0.079
0.281
SD
21.479
0.004
0.024
0.071
0.221
0.201
0.047
0.021
0.028
0.013
0.077
Reference
Mean
221.654
0.035
0.345
0.936
0.687
3.167
0.695
0.217
0.161
0.080
0.323
Item 1000
SD
19.352
0.006
0.023
0.075
0.129
0.295
0.043
0.031
0.028
0.016
0.106
n= number of animals, = statistically significant increase/decrease as compared to control-G1 (p<0.05), and = statistically significant increase/decrease as compared to control-G1 (p<0.01).
