An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin

Table 5

Summary of results for the mouse micronucleus test.

Groups; n=5	Polychromatic Erythrocytes/Total Erythrocytes; Mean ± SD		MN – PCE; (mean & SD)		Total MNPCE
	Male	Female	Male	Female	Male	Female
Vehicle Control	0.515 ± 0.03	0.517 ± 0.02	0.030 ± 0.02	0.040 ± 0.01	06	08
500 mg/kg bw	0.517 ± 0.01	0.524 ± 0.01	0.025 ± 0.02	0.035 ± 0.02	05	07
1000 mg/kg bw	0.520 ± 0.01	0.520 ± 0.01	0.035 ± 0.02	0.040 ± 0.02	07	08
2000 mg/kg bw	0.521 ± 0.01	0.521 ± 0.00	0.035 ± 0.02	0.035 ± 0.01	07	07
Positive control; 30 mg/kg bw	0.481 ± 0.02	0.477 ± 0.01	1.042   ± 0.17	1.053   ± 0.14	209	211
Historical Vehicle Control Data	0.545 ± 0.063	0.567 ± 0.056	0.045 ± 0.051	0.072 ± 0.065	NA	NA

Note. Vehicle control, 0.5 % w/v carboxymethylcellulose; SD, standard deviation; positive control, CP-cyclophosphamide monohydrate; test item, curcumin in mg/kg bw.