Ameliorating Iron Overload in Intestinal Tissue of Adult Male Rats: Quercetin vs Deferoxamine
Table 4
Effects of Quercetin in comparison to DFO on IL6 and IL10 of small intestinal tissues in iron overloaded rats.
Groups
IL6(pg/ml)
IL10(pg/ml)
Duodenum
Jejunum
Ilium
Duodenum
Jejunum
Ilium
Control
30.31±0.28
30.24±0.26
29.78±0.25
13.57±0.57
13.65±0.55
13.45±0.044
DFO
29.87±0.24
29.88±0.26
29.66±0.24
13.37±0.59
13.34±0.57
13.33 ±0.051
Quercetin
29.46±0.16
29.44±0.18
29.44±0.16
12.89±0.54
12.80±0.55
12.55±0.45
Iron
88.86±0.57 a
94.76±0.61 a
99.89±0.57 a
7.43±0.16 a
7.01±0.14 a
6.34±0.11 a
Iron + DFO
47.99±1.64 b
44.57±1.43 b
47.34±1.6 b
13.04±0.42 b
12.89±0.44 b
12.79±0.53 b
Iron+Quercetin
48.91±1.79 b,c
45.67±1.77b,c
48.24±1.79b,c
12.49±0.18 b,c
12.77±0.14b,c
12.69±0.11b,c
P-Value
0.001
0.001
0.001
0.001
0.001
0.001
LSD 0.05
2.9612
2.933
2.876
1.2821
1.2835
1.3215
Values are expressed as means ±standard error (n=6), LSD: least significance difference, DFO: deferoxamine, a: highly significant difference as compared to control group (P< 0.001). b: highly significant difference as compared to iron overload group (P< 0.001). c: nonsignificant difference as compared to iron + DFO group (P > 0.05).
