An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp : Table 11

Table 11: Summary of selected† clinical chemistry findings in the 90-day repeated oral toxicity study.


Group	ALT	AST	GGT	ALP	TBIL	CREA	CHOL	Pi	ALB	TPROT
(mg/kg bw/day)	U/L	U/L	U/L	U/L	μmol/L	μmol/L	mmol/L	mmol/L	g/L	g/L

Male (main groups, = 10 each)
Control	65.11 ± 15.73	98.99 ± 17.04	1.21 ± 0.23	129.10 ± 35.04	1.93 ± 0.43	28.84 ± 2.54	1.90 ± 0.22	1.93 ± 0.24	34.81 ± 0.60	61.99 ± 2.53
100	52.96 ± 9.36	95.25 ± 9.39	1.27 ± 0.36	124.80 ± 40.28	1.52 ± 0.25	27.83 ± 2.98	1.86 ± 0.38	2.26 ± 0.53	35.38 ± 1.15	64.65 ± 3.49
360	62.35 ± 16.31	83.03 ± 6.33	2.11 ± 0.67∗∗	129.90 ± 43.44	1.70 ± 0.24	29.01 ± 2.29	1.84 ± 0.26	2.38 ± 0.34	36.11 ± 1.41	66.90 ± 5.38
720	51.50 ± 11.56	88.31 ± 11.96	3.44 ± 1.06∗∗	161.60 ± 38.08	1.87 ± 0.33	29.27 ± 3.56	1.68 ± 0.42	2.10 ± 0.37	36.47 ± 1.78∗∗	67.29 ± 4.40
Historical range♮	28.0–86.2	67.9–135.7	0.0–2.2	56–184	0.71–2.79	18.5 ± 37.2	1.27–2.44	1.40–2.41	33.0–37.4	56.8–68.0

Male (recovery groups, = 5 each)
Control	57.56 ± 15.48	89.22 ± 11.97	0.98 ± 0.18	104.60 ± 27.83	1.61 ± 0.30	30.42 ± 2.46	2.22 ± 0.29	1.95 ± 0.37	35.38 ± 0.88	66.48 ± 3.33
720	48.70 ± 17.40	76.78 ± 11.47	1.48 ± 0.16∗∗	89.00 ± 16.00	1.78 ± 0.41	30.56 ± 4.48	1.82 ± 0.42	2.08 ± 0.28	36.00 ± 0.99	65.58 ± 3.27

Female (main groups, = 10 each)
Control	52.32 ± 7.80	85.88 ± 10.45	1.54 ± 0.29	55.80 ± 16.72	1.78 ± 0.22	31.81 ± 2.69	1.94 ± 0.38	1.59 ± 0.23	35.35 ± 1.23	62.16 ± 2.61
100	51.04 ± 10.64	91.17 ± 22.32	1.35 ± 0.47	64.70 ± 26.19	1.91 ± 0.39	30.36 ± 2.30	1.80 ± 0.27	1.96 ± 0.36	36.18 ± 1.50	64.78 ± 2.63
360	51.40 ± 8.64	84.86 ± 12.67	3.11 ± 0.74∗∗	72.70 ± 22.96	1.60 ± 0.25	30.85 ± 3.33	2.19 ± 0.32	1.99 ± 0.35∗∗	36.33 ± 1.21	64.62 ± 2.83
720	58.11 ± 11.93	85.12 ± 15.40	7.41 ± 1.72∗∗	91.10 ± 23.86∗∗	2.13 ± 0.69	30.37 ± 2.35	2.71 ± 0.41∗∗	1.84 ± 0.15∗∗	35.90 ± 1.84	65.15 ± 4.63
Historical range♮	23.4–87.7	71.0–141.8	0.0–2.9	25.0–126	1.23–3.30	25.6–40.8	1.35–3.39	0.93–2.01	33.2–41.0	57.1–74.5

Female (recovery groups, = 5 each)
Control	48.12 ± 13.64	73.58 ± 11.26	1.06 ± 0.15	53.60 ± 13.94	2.03 ± 0.28	34.44 ± 2.50	2.37 ± 0.50	1.39 ± 0.32	37.28 ± 2.70	68.94 ± 5.95
720	38.40 ± 4.83	70.44 ± 10.04	1.96 ± 0.46∗∗	49.60 ± 10.36	1.78 ± 0.24	30.72 ± 2.12	2.22 ± 0.31	1.22 ± 0.28	36.76 ± 1.09	66.44 ± 1.28

Data represent the mean values and the standard deviation.
†: only parameters with statistically significant findings are shown in table.
and ∗∗P < 0.01, statistical significances were determined with Duncan's multiple range test or with Mann–Whitney test versus control.
♮: minimum and maximum levels reported as the range of historical control values.