Table 11: Summary of selected† clinical chemistry findings in the 90-day repeated oral toxicity study.

GroupALTASTGGTALPTBILCREACHOLPiALBTPROT
(mg/kg bw/day)U/LU/LU/LU/Lμmol/Lμmol/Lmmol/Lmmol/Lg/Lg/L

Male (main groups, = 10 each)
Control65.11 ± 15.7398.99 ± 17.041.21 ± 0.23129.10 ± 35.041.93 ± 0.4328.84 ± 2.541.90 ± 0.221.93 ± 0.2434.81 ± 0.6061.99 ± 2.53
10052.96 ± 9.3695.25 ± 9.391.27 ± 0.36124.80 ± 40.281.52 ± 0.2527.83 ± 2.981.86 ± 0.382.26 ± 0.5335.38 ± 1.1564.65 ± 3.49
36062.35 ± 16.3183.03 ± 6.332.11 ± 0.67∗∗129.90 ± 43.441.70 ± 0.2429.01 ± 2.291.84 ± 0.262.38 ± 0.3436.11 ± 1.4166.90 ± 5.38
72051.50 ± 11.5688.31 ± 11.963.44 ± 1.06∗∗161.60 ± 38.081.87 ± 0.3329.27 ± 3.561.68 ± 0.422.10 ± 0.3736.47 ± 1.78∗∗67.29 ± 4.40
Historical range28.0–86.267.9–135.70.0–2.256–1840.71–2.7918.5 ± 37.21.27–2.441.40–2.4133.0–37.456.8–68.0

Male (recovery groups, = 5 each)
Control57.56 ± 15.4889.22 ± 11.970.98 ± 0.18104.60 ± 27.831.61 ± 0.3030.42 ± 2.462.22 ± 0.291.95 ± 0.3735.38 ± 0.8866.48 ± 3.33
72048.70 ± 17.4076.78 ± 11.471.48 ± 0.16∗∗89.00 ± 16.001.78 ± 0.4130.56 ± 4.481.82 ± 0.422.08 ± 0.2836.00 ± 0.9965.58 ± 3.27

Female (main groups, = 10 each)
Control52.32 ± 7.8085.88 ± 10.451.54 ± 0.2955.80 ± 16.721.78 ± 0.2231.81 ± 2.691.94 ± 0.381.59 ± 0.2335.35 ± 1.2362.16 ± 2.61
10051.04 ± 10.6491.17 ± 22.321.35 ± 0.4764.70 ± 26.191.91 ± 0.3930.36 ± 2.301.80 ± 0.271.96 ± 0.3636.18 ± 1.5064.78 ± 2.63
36051.40 ± 8.6484.86 ± 12.673.11 ± 0.74∗∗72.70 ± 22.961.60 ± 0.2530.85 ± 3.332.19 ± 0.321.99 ± 0.35∗∗36.33 ± 1.2164.62 ± 2.83
72058.11 ± 11.9385.12 ± 15.407.41 ± 1.72∗∗91.10 ± 23.86∗∗2.13 ± 0.6930.37 ± 2.352.71 ± 0.41∗∗1.84 ± 0.15∗∗35.90 ± 1.8465.15 ± 4.63
Historical range23.4–87.771.0–141.80.0–2.925.0–1261.23–3.3025.6–40.81.35–3.390.93–2.0133.2–41.057.1–74.5

Female (recovery groups, = 5 each)
Control48.12 ± 13.6473.58 ± 11.261.06 ± 0.1553.60 ± 13.942.03 ± 0.2834.44 ± 2.502.37 ± 0.501.39 ± 0.3237.28 ± 2.7068.94 ± 5.95
72038.40 ± 4.8370.44 ± 10.041.96 ± 0.46∗∗49.60 ± 10.361.78 ± 0.2430.72 ± 2.122.22 ± 0.311.22 ± 0.2836.76 ± 1.0966.44 ± 1.28

Data represent the mean values and the standard deviation.
†: only parameters with statistically significant findings are shown in table.
and ∗∗P < 0.01, statistical significances were determined with Duncan's multiple range test or with Mann–Whitney test versus control.
: minimum and maximum levels reported as the range of historical control values.