Table 12: Summary of organ weights (g) in the 90-day repeated oral toxicity study.

Group (mg/kg bw/day)Body weightBrainLiverKidneysHeartThymusSpleenTestes/uterusEpididymides/ovariesAdrenalsThyroid

Male (main groups, = 10 each)
Control383.3 ± 27.862.06 ± 0.149.65 ± 0.952.12 ± 0.181.09 ± 0.090.40 ± 0.090.64 ± 0.113.45 ± 0.201.68 ± 0.130.068 ± 0.0080.023 ± 0.006
100374.1 ± 42.852.02 ± 0.099.70 ± 1.042.13 ± 0.271.05 ± 0.140.35 ± 0.080.59 ± 0.073.48 ± 0.291.59 ± 0.140.072 ± 0.0080.020 ± 0.006
360345.7 ± 18.90∗∗2.01 ± 0.1111.05 ± 0.79∗∗2.04 ± 0.160.94 ± 0.09∗∗0.31 ± 0.090.55 ± 0.093.24 ± 0.271.48 ± 0.16∗∗0.080 ± 0.0120.022 ± 0.004
720329.4 ± 18.86∗∗2.02 ± 0.1213.50 ± 1.37∗∗2.08 ± 0.150.95 ± 0.08∗∗0.29 ± 0.07∗∗0.55 ± 0.073.29 ± 0.251.36 ± 0.11∗∗0.080 ± 0.0120.023 ± 0.005
Historical range344–4881.81–2.397.95–14.141.79–2.730.97–1.500.23–0.840.26–0.962.58–4.201.39–1.930.047–0.0970.015–0.038

Male (recovery group, = 5 each)
Control434.0 ± 16.082.07 ± 0.0110.65 ± 0.442.26 ± 0.081.02 ± 0.040.38 ± 0.070.68 ± 0.083.50 ± 0.091.81 ± 0.090.071 ± 0.0070.025 ± 0.002
720373.2 ± 19.25∗∗2.05 ± 0.068.93 ± 0.81∗∗2.19 ± 0.090.99 ± 0.030.36 ± 0.070.63 ± 0.083.51 ± 0.291.71 ± 0.080.063 ± 0.0030.026 ± 0.003

Female (main groups, = 10 each)
Control239.0 ± 18.901.97 ± 0.126.42 ± 0.401.49 ± 0.160.77 ± 0.070.30 ± 0.040.55 ± 0.100.79 ± 0.230.159 ± 0.0250.083 ± 0.0130.023 ± 0.005
100234.6 ± 15.971.88 ± 0.156.70 ± 0.561.43 ± 0.090.76 ± 0.050.37 ± 0.05∗∗0.46 ± 0.06∗∗0.59 ± 0.130.145 ± 0.0410.084 ± 0.0140.020 ± 0.005
360224.3 ± 13.141.91 ± 0.137.40 ± 0.60∗∗1.34 ± 0.130.71 ± 0.080.33 ± 0.060.43 ± 0.06∗∗0.50 ± 0.20∗∗0.141 ± 0.0250.093 ± 0.0130.020 ± 0.005
720213.4 ± 11.75∗∗1.88 ± 0.079.21 ± 0.54∗∗1.36 ± 0.100.69 ± 0.060.30 ± 0.030.36 ± 0.05∗∗0.46 ± 0.12∗∗0.140 ± 0.0370.100 ± 0.0120.023 ± 0.009
Historical range206–2851.75–2.185.30–7.971.23–2.000.66–0.960.24–0.540.33–0.750.40–2.070.098–0.2080.063–0.1130.012–0.029

Female (recovery group, = 5 each)
Control248.4 ± 8.732.04 ± 0.056.63 ± 0.451.57 ± 0.110.74 ± 0.050.38 ± 0.050.49 ± 0.040.72 ± 0.100.139 ± 0.0300.071 ± 0.0090.022 ± 0.002
720217.2 ± 9.58∗∗1.92 ± 0.03∗∗5.86 ± 0.21∗∗1.37 ± 0.07∗∗0.67 ± 0.040.33 ± 0.030.43 ± 0.040.48 ± 0.10∗∗0.130 ± 0.0310.075 ± 0.0050.024 ± 0.002

Data represent the mean values and the standard deviation.
and ∗∗ P < 0.01, statistical significances were determined with Duncan's multiple range test or with Mann–Whitney test versus control.
: minimum and maximum levels reported as the range of historical control values.