Table 14: Summary of relative organ weights (organ and body weight relative to brain weight) (%) in the 90-day repeated oral toxicity study.

Group (mg/kg bw/day)Body weightLiverKidneysHeartThymusSpleenTestes/uterusEpididymides/ovariesAdrenalsThyroid

Male (main groups, = 10 each)
Control18591.6 ± 968.39468.24 ± 40.18102.89 ± 6.6552.69 ± 3.6919.15 ± 3.6330.70 ± 4.40167.49 ± 8.2081.70 ± 8.273.31 ± 0.391.09 ± 0.28
10018490.1 ± 1785.06479.69 ± 46.21105.21 ± 11.5651.68 ± 5.9717.48 ± 3.7128.94 ± 3.10172.03 ± 13.7078.46 ± 6.783.57 ± 0.451.01 ± 0.34
36017293.5 ± 1365.76552.65 ± 49.26∗∗102.35 ± 11.9946.98 ± 5.1715.64 ± 4.2327.28 ± 4.46161.87 ± 16.3474.05 ± 7.674.02 ± 0.61∗∗1.11 ± 0.22
72016340.7 ± 1594.47∗∗670.06 ± 90.43∗∗103.09 ± 10.6547.16 ± 3.9814.29 ± 3.4327.46 ± 4.11163.26 ± 16.0567.57 ± 6.46∗∗3.96 ± 0.50∗∗1.14 ± 0.25
Historical range16681–22689371.50–660.2091.59–131.2543.53–65.2210.45–38.1811.82–41.71129.65–186.0563.76–98.402.19–4.320.78–1.80

Male (recovery group, = 5 each)
Control20923.4 ± 682.77513.36 ± 19.85109.06 ± 3.3349.28 ± 2.0918.12 ± 3.1932.97 ± 3.96168.56 ± 3.7187.37 ± 4.303.44 ± 0.341.19 ± 0.07
72018234.7 ± 1067.39∗∗435.79 ± 31.87∗∗106.81 ± 1.7148.18 ± 2.3417.79 ± 3.5430.55 ± 3.78171.55 ± 16.9683.77 ± 5.213.07 ± 0.231.25 ± 0.14

Female (main groups, = 10 each)
Control12135.2 ± 419.40326.63 ± 20.9475.83 ± 6.2039.04 ± 3.1115.47 ± 2.1627.91 ± 3.9839.68 ± 10.638.11 ± 1.304.22 ± 0.511.16 ± 0.27
10012513.6 ± 1162.30357.88 ± 44.8476.19 ± 6.9340.48 ± 4.5519.89 ± 3.29∗∗24.50 ± 3.3431.50 ± 6.987.74 ± 2.234.50 ± 0.951.04 ± 0.25
36011848.4 ± 1337.88391.14 ± 50.90∗∗70.90 ± 9.8937.63 ± 6.7117.29 ± 4.2022.74 ± 4.47∗∗26.75 ± 12.08∗∗7.46 ± 1.704.89 ± 0.791.06 ± 0.23
72011377.7 ± 735.76490.87 ± 33.83∗∗72.47 ± 6.1736.65 ± 3.1715.97 ± 2.0619.19 ± 2.33∗∗24.65 ± 6.98∗∗7.41 ± 1.835.32 ± 0.70∗∗1.24 ± 0.44
Historical range10600.0–14685.7276.04–412.9565.08–104.7133.65–49.7411.82–27.5517.84–38.3418.96–99.525.19–10.793.12–5.490.65–1.53

Female (recovery group, = 5 each)
Control12200.5 ± 339.93325.87 ± 21.6577.26 ± 4.2236.44 ± 2.2518.49 ± 2.7523.86 ± 1.7935.34 ± 4.816.84 ± 1.583.47 ± 0.381.10 ± 0.06
72011316.1 ± 560.61305.45 ± 14.3471.15 ± 3.8535.03 ± 2.8117.19 ± 1.4222.18 ± 1.8624.95 ± 5.066.78 ± 1.553.90 ± 0.251.23 ± 0.11

Data represent the mean values and the standard deviation.
and ∗∗P < 0.01, statistical significances were determined with Duncan's multiple range test or with Mann–Whitney test versus control.
: minimum and maximum levels reported as the range of historical control values.