Table 8
(a) Summary of mean body weight gain in the 90-day repeated oral toxicity study

Group (mg/kg bw/day)Body weight gain (g) between days
0-33-77-1010-1414-1717-2121-2424-2828-3535-4242-4949-5656-6363-7070-7777-8484-890–89

Males
 Control19.5 ± 2.324.3 ± 3.018.3 ± 1.419.2 ± 3.714.9 ± 2.714.4 ± 3.011.3 ± 2.812.3 ± 2.820.7 ± 2.712.9 ± 2.913.3 ± 3.88.7 ± 3.58.8 ± 2.810.2 ± 2.96.1 ± 3.511.3 ± 3.60.2 ± 2.3226.5 ± 24.5
 10019.3 ± 3.223.6 ± 4.316.9 ± 4.419.5 ± 6.115.2 ± 3.914.2 ± 4.612.3 ± 3.211.6 ± 3.320.5 ± 5.312.4 ± 2.511.5 ± 4.95.8 ± 2.97.0 ± 5.68.4 ± 2.61.6 ± 3.7∗∗10.7 ± 2.83.6 ± 3.4214.1 ± 40.6
 3609.6 ± 4.8∗∗18.7 ± 2.9∗∗15.7 ± 3.315.8 ± 2.713.9 ± 3.012.8 ± 2.210.7 ± 2.310.5 ± 1.917.5 ± 3.212.4 ± 4.09.6 ± 5.1 4.9 ± 4.98.8 ± 2.69.5 ± 3.73.0 ± 2.712.2 ± 4.51.7 ± 5.0187.3 ± 20.2∗∗
 7203.9 ± 3.5∗∗17.9 ± 4.5∗∗12.3 ± 5.9∗∗16.9 ± 3.110.9 ± 3.7∗∗13.7 ± 3.69.4 ± 2.710.5 ± 2.114.9 ± 4.3∗∗12.9 ± 4.08.7 ± 2.8∗∗7.9 ± 3.26.3 ± 3.08.4 ± 2.71.1 ± 2.5∗∗12.5 ± 3.61.3 ± 2.8169.7 ± 15.0∗∗

Females
 Control10.8 ± 2.412.1 ± 1.58.5 ± 3.28.6 ± 3.78.9 ± 2.96.7 ± 2.07.1 ± 3.26.3 ± 1.712.0 ± 5.18.2 ± 3.57.6 ± 4.03.8 ± 3.16.3 ± 4.24.8 ± 3.00.5 ± 3.08.5 ± 3.4-0.6 ± 3.1120.2 ± 14.5
 1009.1 ± 2.311.2 ± 2.67.7 ± 3.19.1 ± 3.48.4 ± 4.77.3 ± 3.98.5 ± 2.06.6 ± 2.810.7 ± 4.16.0 ± 2.77.8 ± 5.13.7 ± 3.34.9 ± 3.55.7 ± 4.2-1.5 ± 3.510.9 ± 5.40.3 ± 4.7116.4 ± 16.7
 3605.3 ± 3.4∗∗10.8 ± 2.67.7 ± 2.39.9 ± 1.09.3 ± 2.87.5 ± 2.87.4 ± 3.45.7 ± 2.713.8 ± 4.06.6 ± 2.54.7 ± 2.34.8 ± 2.64.9 ± 3.23.1 ± 3.00.7 ± 2.86.7 ± 2.61.3 ± 3.1110.2 ± 12.0
 7200.8 ± 3.3∗∗8.4 ± 3.6∗∗8.1 ± 2.110.3 ± 2.98.7 ± 2.59.0 ± 1.6∗∗6.4 ± 1.77.0 ± 2.48.5 ± 2.57.4 ± 2.04.9 ± 2.43.1 ± 2.05.1 ± 2.12.7 ± 1.8-1.6 ± 2.76.5 ± 2.61.8 ± 2.997.2 ± 9.0∗∗

= 15 in control and 720 mg/kg bw/day groups; in all other groups = 10.
p < 0.05, ∗∗p < 0.01, statistical significances were determined with Duncan's multiple range test or with Mann–Whitney test versus control.
(b) Summary of mean body weight gain in the recovery period

Group (mg/kg bw/day)Body weight gain (g) between days
89–9696–103103–110110–11789–117

Males
 Control12.0 ± 2.79.4 ± 3.69.2 ± 3.55.0 ± 3.135.6 ± 3.0
 7208.0 ± 4.115.8 ± 4.112.8 ± 5.911.4 ± 5.148.0 ± 12.6

Females
 Control0.6 ± 2.23.0 ± 3.55.0 ± 1.62.2 ± 4.310.8 ± 4.4
 7200.2 ± 4.52.4 ± 2.32.4 ± 7.16.4 ± 5.911.4 ± 3.8

= 5 for all groups.
p < 0.05, ∗∗p < 0.01, statistical significances were determined with Duncan's multiple range test or with Mann–Whitney test versus control.