MeHg Causes Ultrastructural Changes in Mitochondria and Autophagy in the Spinal Cord Cells of Chicken Embryo

Figure 4

Effect of MeHg on vacuole formation in spinal cord cells of E10 embryos. Electron micrograph of the mantle layer showing the mitophagic profile in the black box (a). The insert in (b) shows a detail of mitochondria (M) surrounded by the autophagic vacuole membrane (white arrowhead). In detail (b) internal mitochondrial membranes (asterisk) and external mitochondrial membranes (double asterisk) are visible. Endoplasmic reticulum (ER) can be seen close to the autophagic vacuole (A) maintaining contact with it by membrane extensions (black arrowhead). Scale bars: (a) 500 μm; (b) 200 ηm.

(a)

(b)