Table of Contents Author Guidelines Submit a Manuscript
Journal of Toxicology
Volume 2018, Article ID 8978731, 8 pages
https://doi.org/10.1155/2018/8978731
Review Article

Cinnamon in Anticancer Armamentarium: A Molecular Approach

UGC-DAE Consortium for Scientific Research, Kolkata Centre, Sector-III, Block-LB-8, Salt Lake, Kolkata, West Bengal 700106, India

Correspondence should be addressed to Anindita Chakraborty; moc.liamg@cui.atidnina

Received 27 October 2017; Revised 13 February 2018; Accepted 25 February 2018; Published 29 March 2018

Academic Editor: Adekunle B. Okesina

Copyright © 2018 Anindita Dutta and Anindita Chakraborty. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. American Cancer Society, Global Cancer Facts & Figures, American Cancer Society, Atlanta, Ga, USA, 2nd edition, 2011.
  2. N. W. Schoene, M. A. Kelly, M. M. Polansky, and R. A. Anderson, “Water-soluble polymeric polyphenols from cinnamon inhibit proliferation and alter cell cycle distribution patterns of hematologic tumor cell lines,” Cancer Letters, vol. 230, no. 1, pp. 134–140, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. S. J. Koppikar, A. S. Choudhari, S. A. Suryavanshi, S. Kumari, S. Chattopadhyay, and R. Kaul-Ghanekar, “Aqueous Cinnamon Extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential,” BMC Cancer, vol. 10, article no. 210, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Hussain, K. Brahmbhatt, A. Priyani, M. Ahmed, T. A. Rizvi, and C. Sharma, “Eugenol enhances the chemotherapeutic potential of gemcitabine and induces anticarcinogenic and anti-inflammatory activity in human cervical cancer cells,” Cancer Biotherapy and Radiopharmaceuticals, vol. 26, no. 5, pp. 519–527, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. S. K. Jaganathan, A. Mazumdar, D. Mondhe, and M. Mandal, “Apoptotic effect of eugenol in human colon cancer cell lines,” Cell Biology International, vol. 35, no. 6, pp. 607–615, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. C.-B. Yoo, K.-T. Han, K.-S. Cho et al., “Eugenol isolated from the essential oil of Eugenia caryophyllata induces a reactive oxygen species-mediated apoptosis in HL-60 human promyelocyticleukemia cells,” Cancer Letters, vol. 225, no. 1, pp. 41–52, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Ghosh, M. Ganapathy, W. L. Alworth, D. C. Chan, and A. P. Kumar, “Combination of 2-methoxyestradiol (2-ME2) and eugenol for apoptosis induction synergistically in androgen independent prostate cancer cells,” The Journal of Steroid Biochemistry and Molecular Biology, vol. 113, no. 1-2, pp. 25–35, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. L.-T. Ng and S.-J. Wu, “Antiproliferative activity of Cinnamomum cassia constituents and effects of pifithrin-alpha on their apoptotic signaling pathways in Hep G2 cells,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 492148, 6 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. S.-J. Wu, L.-T. Ng, and C.-C. Lin, “Cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells through activation of the proapoptotic Bcl-2 family proteins and MAPK pathway,” Life Sciences, vol. 77, no. 8, pp. 938–951, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Ka, H.-J. Park, and H.-J. Jung, “Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells,” Cancer Letters, vol. 196, no. 2, pp. 143–152, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. K.-R. Park, D. Nam, H.-M. Yun et al., “β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation,” Cancer Letters, vol. 312, no. 2, pp. 178–188, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. H.-K. Kwon, W. K. Jeon, J.-S. Hwang et al., “Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells,” Cancer Letters, vol. 278, no. 2, pp. 174–182, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. D. Pal, S. Banerjee, S. Mukherjee, A. Roy, C. K. Panda, and S. Das, “Eugenol restricts DMBA croton oil induced skin carcinogenesis in mice: downregulation of c-Myc and H-ras, and activation of p53 dependent apoptotic pathway,” Journal of Dermatological Science, vol. 59, pp. 31–39, 2010. View at Publisher · View at Google Scholar
  14. X. Q. Yang, H. Zheng, Q. Ye, R. Y. Li, and Y. Chen, “Essential oil of cinnamon exerts anti-cancer activity against head and neck squamous cell carcinoma via attenuating epidermal growth factor receptor – tyrosine kinase,” Journal of the Balkan Union of Oncology, vol. 20, pp. 1518–1525, 2015. View at Google Scholar
  15. X. Han and T. L. Parker, “Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model,” Phytotherapy Research, vol. 31, no. 7, pp. 1034–1038, 2017. View at Publisher · View at Google Scholar · View at Scopus
  16. H.-K. Kwon, J.-S. Hwang, J.-S. So et al., “Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1,” BMC Cancer, vol. 10, no. 1, article 392, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Kaur, M. Athar, and M. Sarwar Alam, “Eugenol precludes cutaneous chemical carcinogenesis in mouse by preventing oxidative stress and inflammation and by inducing apoptosis,” Molecular Carcinogenesis, vol. 49, no. 3, pp. 290–301, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. J.-H. Zhang, L.-Q. Liu, Y.-L. He, W.-J. Kong, and S.-A. Huang, “Cytotoxic effect of trans-cinnamaldehyde on human leukemia K562 cells,” Acta Pharmacologica Sinica, vol. 31, no. 7, pp. 861–866, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. S.-H. Hong, I. A. Ismail, S.-M. Kang, D. C. Han, and B.-M. Kwon, “Cinnamaldehydes in Cancer Chemotherapy,” Phytotherapy Research, vol. 30, no. 5, pp. 754–767, 2016. View at Publisher · View at Google Scholar · View at Scopus