Toxicity Evaluation of a Novel Magnetic Resonance Imaging Marker, CoCl2-N-Acetylcysteine, in Rats
Table 2
Clinical chemistry findings.
Time after Injection and Treatment Group
Total Bilirubin,
Creatinine,
Blood Urea Nitrogen,
Aspartate Transaminase,
Alkaline Aminotransferase,
Alkaline Phosphatase,
Total Protein,
Albumin,
Globulin,
mg/dL
mg/dL
mg/dL
mg/dL
IU/L
IU/L
g/dL
g/dL
g/dL
Day 2
Control
0.1 (0.1)
0.3 (0.28-0.32)
15.80 (14.2-16.7)
219 (122-445)
175 (54-441)
168 (98-228)
6.18 (5.58-6.59)
4.21 (4.01-4.60)
1.97 (1.57-2.30)
Low dose
0.1 (0.1)
0.3 (0.28-0.35)
16.40 (14.8-18.8)
283 (121-869)
266 (78-921)
208 (132-306)
6.23 (5.83-6.74)
4.16 (4.11-4.22)
2.07 (1.72-2.61)
Ref dose
0.1 (0.1)
0.27 (0.24-0.30)
16.9 (15.9-19.6)
199 (68-491)
173 (44-428)
201 (175-239)
6.1 (5.88-6.28)
4.2 (4.09-4.35)
1.9 (1.53-2.18)
High dose
0.1 (0.1)
0.29 (0.25-0.34)
16.1 (14.0-18.8)
132 (70-318)
99 (44-244)
167 (144-230)
6.21 (5.82-6.44)
4.04 (3.87-4.16)
2.17 (1.95-2.45)
Day 28
Control
<0.1 (<0.01)
0.32 (0.28-0.35)
17.9 (16.2-19.5)
– (154->3836)†
– (48->4070)†
186 (141-252)
6.3 (5.98-6.95)
4.26 (4.17-4.47)
2.04 (1.78-2.48)
Low dose
<0.01 (<0.01)
0.31 (0.27-0.34)
20.1 (17.3-24.6)
– (123->964)†
– (65->921)†
202 (173-258)
6.36 (5.91-6.74)
4.18 (3.95-4.36)
2.17 (1.76-2.66)
Ref dose
<0.01 (<0.01)
0.32 (0.29-0.37)
12.2 (15.8-20.2)
– (56->2530)†
– (45->3030)†
140 (128-163)
6.68 (6.34-6.83
4.19 (4.04-4.31)
2.49 (2.30-2.65)
High dose
<0.01 (<0.01)
0.31 (0.31->0.69)†
19.3 (17.4-21.4)
– (59->7000)†
– (45->7000)†
210 (131-287)
6.87 (6.39-7.87)
4.32 (4.11-4.60)
2.51 (2.13-3.27)
Day 63
Control
0.1 (0.1)
0.34 (0.32-0.36)
19.9 (18.8-21.4)
135 (68-325)
141 (41-473)
141 (111-195)
6.89 (6.56-7.21)
4.33 (4.21-4.44)
2.56 (2.21-2.88)
Low dose
0.1 (0.1)
0.33 (0.31-0.35)
20.7 (17.6-23.6)
142 (84-266)
113 (52-239)
165 (127-206)
7.01 (6.69-7.70)
4.40 (4.14-4.90)
2.61 (2.48-2.80)
Ref dose
0.1 (0.1)
0.32 (0.30-0.35)
19.6 (17.9-21.7)
247 (180-336)
193 (153-230)
149 (89-235)
6.57 (6.26-7.10)
4.22 (3.98-4.58)
2.36 (2.00-2.52)
High dose
0.1 (0.1)
0.31 (0.26-0.33)
18.4 (16.9-19.5)
136 (67-232)
114 (39-233)
115 (100-135)
6.73 (6.27-7.33)
4.16 (3.89-4.57)
2.57 (2.38-3.07)
Data are shown as mean (range). Significantly different from control at < 0.05. †Out of range because of hemolysis. Control, 0% CoCl2:NAC; Low dose, 0.1% CoCl2:2% NAC; Ref[erence] dose, 1% CoCl2:2% NAC; High dose, 10% CoCL2: 2% NAC.
