Journal of Toxicology / 2019 / Article / Tab 2

Research Article

Potential Toxicity of the Essential Oil from Minthostachys mollis: A Medicinal Plant Commonly Used in the Traditional Andean Medicine in Peru

Table 2

Biochemical parameters of rats after treatment with repeated oral doses of Minthostachys mollis essential oil (Mm-EO) for 28 days.

ParametersControlMm-EO 100Mm-EO 250Mm-EO 500

Males
AST (IU/L)144.33 ± 6.81161.67 ± 9.07171.33 ± 11.37n.d.
ALT (IU/L)61.67 ± 13.6180.33 ± 10.0299.00 ± 11.53n.d.
Alkaline phosphatase (IU/L)175.67 ± 9.29176.33 ± 4.04181.00 ± 11.53n.d.
Total bilirubin (mg/dL)0.61 ± 0.130.62 ± 0.070.65 ± 0.06n.d.
Total protein (g/dL)7.23 ± 0.617.33 ± 0.617.53 ± 0.32n.d.
Albumin (g/dL)3.70 ± 0.363.90 ± 0.263.83 ± 0.49n.d.
Cholesterol (mg/dL)69.83 ± 4.2565.40 ± 9.1850.67 ± 8.33n.d.
Triglycerides (mg/dL)102.00 ± 11.7979.33 ± 13.0141.00 ± 8.89n.d.
HDL (mg/dL)30.77 ± 4.6834.00 ± 5.1435.13 ± 3.56n.d.
LDL (mg/dL)18.66 ± 2.5515.53 ± 3.227.34 ± 2.19n.d.
Glucose (mg/dL)116.10 ± 8.65108.43 ± 11.76112.17 ± 7.52n.d.
Urea (mg/dL)34.00 ± 4.3633.50 ± 3.1229.83 ± 1.61n.d.
Creatinine (mg/dL)0.94 ± 0.080.85 ± 0.080.65 ± 0.04n.d.

Females
AST (IU/L)130.33 ± 5.50144.33 ± 15.63155.67 ± 12.89168.33 ± 5.51
ALT (IU/L)58.67 ± 9.7183.67 ± 18.50101.33 ± 11.37109.00 ± 6.56
Alkaline phosphatase (IU/L)174.00 ± 9.64178.67 ± 17.61177.67 ± 14.19179.33 ± 6.03
Total bilirubin (mg/dL)0.62 ± 0.140.62 ± 0.110.63 ± 0.150.66 ± 0.05
Total protein (g/dL)7.23 ± 0.667.50 ± 0.367.20 ± 0.657.37 ± 0.49
Albumin (g/dL)3.80 ± 0.203.73 ± 0.353.67 ± 0.313.65 ± 0.04
Cholesterol (mg/dL)78.40 ± 10.0558.00 ± 5.0745.27 ± 5.0042.90 ± 3.73
Triglycerides (mg/dL)95.27 ± 11.0882.03 ± 4.2131.33 ± 3.2130.13 ± 2.80
HDL (mg/dL)33.13 ± 4.2734.00 ± 5.6034.03 ± 4.5932.43 ± 2.89
LDL (mg/dL)26.22 ± 5.157.59 ± 2.274.97 ± 0.734.44 ± 1.02
Glucose (mg/dL)119.23 ± 6.49113.23 ± 9.87110.27 ± 14.14115.07 ± 3.58
Urea (mg/dL)35.97 ± 2.3431.53 ± 2.8428.47 ± 4.0532.53 ± 5.06
Creatinine (mg/dL)0.91 ± 0.080.82 ± 0.070.63 ± 0.060.60 ± 0.04

Values are expressed as Mean ± SD, significance when compared with control (). One-way ANOVA followed by Tukey test. AST, Aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; HDL, high-density lipoprotein; LDL, low-density lipoprotein. n.d., not determined because rats died in the first week of treatment.