Safety Assessment of Ubiquinol Acetate: Subchronic Toxicity and Genotoxicity Studies

<table class="fixed-width table-group" id="tab1"><tr><td><table class="table"><colgroup><col style="width:8.37em"/><col style="width:5.04em"/><col style="width:5.19em"/><col style="width:5.34em"/></colgroup><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2">Compound</td><td class="align_center" colspan="3">HPLC Purity (%)</td></tr><tr class="thead"><td class="align_center">Initiation</td><td class="align_center"><svg height="11.2576pt" id="M7" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.2078 13.0997 11.2576" width="13.0997pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,6.24,-5.741)"><path d="M327 325C324 350 312 408 304 433C283 442 256 451 213 451C120 451 59 391 59 320C59 243 125 210 188 181C237 158 266 136 266 93C266 52 231 24 195 24C134 24 93 81 74 148L42 143C42 106 51 37 59 23C78 8 125 -12 177 -12C257 -12 345 35 345 127C345 198 292 234 216 264C171 283 131 305 131 348C131 387 156 416 195 416C243 416 277 378 297 317L327 325Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,9.616,-5.741)"><path d="M303 37L293 66C280 59 256 49 231 49S173 63 173 143V396H281C294 404 298 428 287 439H173V575L158 577L92 509V439H46L17 408L22 396H92V107C92 27 128 -12 192 -12C203 -12 218 -9 237 2L303 37Z"></path></g></svg> month</td><td class="align_center"><svg height="12.3641pt" id="M8" style="vertical-align:-0.2064009pt" version="1.1" viewbox="-0.0498162 -12.1577 15.1366 12.3641" width="15.1366pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M285 378C315 398 338 416 353 432C373 451 384 474 384 503C384 579 325 635 236 635H235C182 635 136 610 108 579L65 516L85 496C110 533 150 575 205 575C258 575 300 543 300 481C300 407 232 369 141 339L147 310C163 315 188 321 211 321C268 321 338 284 338 192C338 94 288 40 217 40C160 40 119 68 93 91C85 98 77 97 69 91C60 84 47 71 46 58C44 46 48 35 62 22C75 10 116 -12 162 -12C234 -12 424 62 424 224C424 297 373 359 285 376V378Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,6.24,-5.741)"><path d="M185 344V453C137 433 92 421 41 413V386C100 378 104 375 104 310V106C104 41 97 35 33 30V0H268V30C190 35 185 41 185 107V283C206 340 240 371 267 371C282 371 296 364 310 351C316 344 325 343 336 348C357 357 369 378 369 399C369 424 345 451 310 451C262 451 219 397 187 344H185Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,9.589,-5.741)"><path d="M526 56L493 58C457 61 448 68 448 119V710C411 697 344 682 288 675V646C362 641 367 639 367 573V439C344 448 315 451 300 451C164 451 40 342 40 202C40 61 147 -12 227 -12C239 -12 266 -7 305 16L367 53V-12C427 10 505 21 526 26V56ZM367 88C342 69 306 54 271 54C207 54 133 111 133 229C133 373 219 409 264 409C301 409 342 394 367 359V88Z"></path></g></svg> month</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">Ubiquinol</td><td class="align_center">98.00</td><td class="align_center">53.00</td><td class="align_center">22.00</td></tr><tr><td class="align_left" colspan="4"><hr/></td></tr><tr><td class="align_left">Ubiquinol acetate</td><td class="align_center">99.50</td><td class="align_center">99.45</td><td class="align_center">99.49</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Stability of ubiquinol and ubiquinol acetate.</div>

Journal of Toxicology

tab1

Table 1

Table 1: Safety Assessment of Ubiquinol Acetate: Subchronic Toxicity and Genotoxicity Studies 