Research Article

Safety Assessment of Ubiquinol Acetate: Subchronic Toxicity and Genotoxicity Studies

Table 14

Summary of histopathological examination, males and females.

OrgansGroup and Dose
DiagnosesG1
01503006000600
TSTSTSTSTSTS
MFMFMFMFMFMF

Lungs(10)(10)(10)(10)(10)(10)(10)(10)(5)(5)(5)(5)
Within normal limits101010977245532
Inflammation, chronic focal/multifocal000123750023
Alveolar macrophages, multifocal000010120000

Liver(10)(10)-(10)-(10)(10)(10)-(5)-(5)
Within normal limits781098542
Fatty change, multifocal31001010
Necrosis, focal/multifocal01001300
Necrosis, single cell, multifocal00010203

Lymph node, mesenteric(10)(10)-(10)-(10)(10)(10)-(5)-(5)
Within normal limits10108110050
Aggregates, macrophages, multifocal002901005

Note: the numerical indicated under observation represents the number of animals with and without lesions; M: male; F: female; TS: terminal sacrifice, : target organs evaluated based on the lesions observed in high dose main study group.