Safety Assessment of Ubiquinol Acetate: Subchronic Toxicity and Genotoxicity Studies
Table 14
Summary of histopathological examination, males and females.
Organs
Group and Dose
Diagnoses
G1
0
150
300
600
0
600
TS
TS
TS
TS
TS
TS
M
F
M
F
M
F
M
F
M
F
M
F
Lungs
(10)
(10)
(10)
(10)
(10)
(10)
(10)
(10)
(5)
(5)
(5)
(5)
Within normal limits
10
10
10
9
7
7
2
4
5
5
3
2
Inflammation, chronic focal/multifocal
0
0
0
1
2
3
7
5
0
0
2
3
Alveolar macrophages, multifocal
0
0
0
0
1
0
1
2
0
0
0
0
Liver
(10)
(10)
-
(10)
-
(10)
(10)
(10)
-
(5)
-
(5)
Within normal limits
7
8
10
9
8
5
4
2
Fatty change, multifocal
3
1
0
0
1
0
1
0
Necrosis, focal/multifocal
0
1
0
0
1
3
0
0
Necrosis, single cell, multifocal
0
0
0
1
0
2
0
3
Lymph node, mesenteric
(10)
(10)
-
(10)
-
(10)
(10)
(10)
-
(5)
-
(5)
Within normal limits
10
10
8
1
10
0
5
0
Aggregates, macrophages, multifocal
0
0
2
9
0
10
0
5
Note: the numerical indicated under observation represents the number of animals with and without lesions; M: male; F: female; TS: terminal sacrifice, : target organs evaluated based on the lesions observed in high dose main study group.