Safety Assessment of Ubiquinol Acetate: Subchronic Toxicity and Genotoxicity Studies

Table 9

Effect of ubiquinol acetate on clinical chemistry parameters in male rats.

Parameters	Units	Group & Dose (mg/kg b.w.)
		G1,	G2,	G3,	G4,	G1R,	G4R,
		0	150	300	600	0	600
Glucose	mg/dL	129.70±18.00	119.00±11.96	122.10±7.68	138.00±22.9	132.40±10.36	125.2±12.62
Blood Urea Nitrogen	mg/dL	16.30±1.77	15.80±2.04	15.50±2.17	17.50±2.42	11.80±0.45	13.40±2.51
Creatinine	mg/dL	0.31±0.05	0.34±0.08	0.38±0.05	0.37±0.05	0.28±0.05	0.30±0.04
Cholesterol	mg/dL	57.60±8.71	57.90±7.88	57.5±6.79	64.00±11.32	68.60±9.07	68.60±8.08
TGL	mg/dL	47.80±13.42	41.20±16.2	43.40±10.46	40.60±8.72	52.00±9.82	50.6±14.42
Total Protein	g/dL	6.64±0.25	6.74±0.13	6.96±0.22	7.17±0.25	6.84±0.13	6.78±0.08
Albumin	g/dL	1.22±0.08	1.25±0.1	1.31±0.12	1.23±0.11	1.22±0.08	1.18±0.13
Total Bilirubin	mg/dL	0.06±0.05	0.10±0.05	0.08±0.04	0.11±0.03	0.10±0.00	0.04±0.05
AST	U/L	68.20±17.63	79.80±22.76	67.70±11.80	81.8±20.32	67.60±2.19	70.00±10.84
Calcium	mg/dL	9.26±0.35	9.26±0.27	9.31±0.39	9.11±0.4	9.62±0.22	9.80±0.35
Phosphorus	mg/dL	5.72±0.48	5.64±0.43	5.70±0.29	5.78±0.15	5.90±0.12	6.12±0.45
ALP	U/L	98.40±19.1	93.50±15.88	94.20±13.25	108.9±21.34	81.80±10.64	77.60±5.37
ALT	U/L	20.00±4.06	24.10±8.41	20.10±3.48	25.70±7.10	22.60±2.51	26.40±6.11
GGT	U/L	2.90±1.37	2.10±0.74	3.00±1.33	2.70±0.82	6.20±0.84	4.80±1.92
Sodium	mmol/L	135.19±1.32	134.40±1.05	136.09±1.7	134.16±1.42	136.94±0.76	135.7±0.61
Potassium	mmol/L	4.19±0.24	4.23±0.35	4.14±0.25	4.32±0.16	4.29±0.17	4.12±0.38
Chloride	mmol/L	107.13±1.19	107.03±0.78	107.53±0.84	107.78±1.85	105.60±0.82	105.22±0.72
Globulin	g/dL	5.42±0.30	5.49±0.18	5.65±0.17	5.94±0.31	5.62±0.16	5.60±0.16

Mean ± SD for 10 rats/sex/group (G1, G2, G3, G4) and 5 rats/sex/group (G1R, G4R); : statistically significant compared to the control group (p < 0.05).