Journal of Toxicology / 2019 / Article / Tab 1

Research Article

A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin

Table 1

Summary of the results of the bacterial reverse mutation test, initial mutation test.

Initial Mutation Test (Plate Incorporation Test)
Concentrations (μg/plate)Salmonella typhimurium tester strainsEscherichia coli
TA 98TA 100TA 1535TA 1537WP2uvrA
-S9+S9-S9+S9-S9+S9-S9+S9-S9+S9
Mean values of revertants per plate mutation rate (MR)MeanMRMeanMRMeanMRMeanMRMeanMRMeanMRMeanMRMeanMRMeanMRMeanMR

Untreated Control21.01.3417.71.0687.31.2488.01.0015.31.0013.01.118.71.188.31.0930.01.0839.31.19
DMSO Control15.71.0016.71.0070.31.0087.71.0015.31.0011.71.007.31.007.71.0027.71.0033.01.00
Ultrapure Water Control68.31.0011.71.0031.31.00

500022.01.4031.31.8868.20.9786.80.9911.70.7613.31.147.81.0711.81.5421.30.7719.80.60
160024.01.5330.31.8268.30.9776.00.8711.30.7411.30.978.71.188.31.0925.30.9228.30.86
50020.71.3222.71.3671.31.0169.30.7914.70.9616.31.406.70.9110.31.3530.31.1032.30.98
16018.01.1519.01.1462.00.8883.30.9511.30.7414.71.267.71.058.31.0933.71.2230.70.93
5016.71.0620.31.2275.31.0794.01.0715.31.0012.01.039.31.2712.01.5728.01.0132.70.99
1620.71.3227.01.6271.31.01102.01.1613.70.8913.71.1710.71.459.71.2623.70.8636.31.10

NPD (4 μg)16364.023.23
SAZ (2 μg)797.311.671162.799.66
9AA (50 μg)604.782.45
MMS (2 μL) 816.026.04
2AA (2 μg)1160.069.601938.722.11152.313.06109.714.30
2AA (50 μg)154.04.67

2AA: 2-aminoanthracene; 9AA: 9-aminoacridine; MMS: methyl methanesulfonate; MR: mutation rate; NPD: 4-nitro-1,2-phenylenediamine; SAZ: sodium azide.
DMSO was the vehicle of the test item and positive control substances: NPD, 9AA, and 2AA; ultrapure water was the vehicle for the SAZ and MMS. The mutation rates of the test item, untreated, and positive controls were calculated using the data from their respective vehicle controls.

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