Journal of Toxicology / 2019 / Article / Tab 3

Research Article

A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin

Table 3

Summary of chromosomal aberration test results.

GroupsExperiment A1
S9 MixTreatmentHarvestMean Aberrant Cells/150 cellsNumber of Aberrations
TimeTimeincl. gapsexcl. gapsincl. gapsexcl. gaps

Test Item
 156.3 μg/mL3 h20 h9494
 312.5 μg/mL3 h20 h8484
 625 μg/mL3 h20 h1382314
Vehicle Control3 h20 h7373
Positive Control3 h20 h37315637
Hist Veh Control43 h20 h4.70–7.821.59–4.11n/an/a

Test Item
 156.3 μg/mL+3 h20 h7585
 312.5 μg/mL+3 h20 h1572312
 625 μg/mL+3 h20 h18102415
Vehicle Control+3 h20 h7384
Positive Control+3 h20 h41366748
Hist Veh Control4+3 h20 h4.66–8.121.69–4.35n/an/a

Experiment B2

Test Item
 19.6 μg/mL20 h20 h9393
 39.1 μg/mL20 h20 h135135
 78.2 μg/mL20 h20 h147167
Vehicle Control20 h20 h8383
Positive Control20 h20 h44396745
Hist Veh Control420 h20 h4.44–7.901.60–4.27n/an/a

Experiment B3

Test Item
 19.6 μg/mL20 h28 h8383
 39.1 μg/mL20 h28 h125146
 78.2 μg/mL20 h28 h187197
Vehicle Control20 h28 h6373
Positive control20 h28 h45356444
Hist Veh Control420 h28 h4.31–7.771.59–4.11n/an/a

Test Item
 156.3 μg/mL+3 h28 h114125
 312.5 μg/mL+3 h28 h137147
 625 μg/mL+3 h28 h21112514
Vehicle Control+3 h28 h7373
Positive Control+3 h28 h43396745
Hist Veh Control4+3 h28 h4.96–7.561.92–4.12n/an/a

Positive controls: (–S9): ethyl methanesulfonate (1.0 μL/mL); (+S9): cyclophosphamide (5.0 μg/mL)
2Positive control: (–S9): ethyl methanesulfonate (0.4 μL/mL)
3Positive controls: (–S9) ethyl methanesulfonate (0.4 μL/mL); (+S9): cyclophosphamide (5.0 μg/mL)
4Numbers reported are the 95% confidence interval
p < 0.05; p < 0.01, to the concurrent vehicle control and to the historical vehicle control
n/a: not applicable; Veh: vehicle; Hist: historical; incl: including; excl: excluding.

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