A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin

Table 4

Summary of mouse micronucleus test results.

Groups		total number of PCE analyzed
mg/kg bw	Sampling		PCE/ PCE+NCE		MPCE
n=5	time, hours		mean	± SD	mean	± SD
Vehicle control	24	20000	0.53	0.02	5.00	1.22
Test item
500	24	20000	0.51	0.01	3.80	0.84
1000	24	20000	0.50	0.01	5.00	1.00
2000	24	20000	0.49	0.01	4.80	1.79
Positive control	24	20000	0.36	0.06	128.6	4.56
Historical Vehicle Control	24	4000	n/a	n/a	4.77	0.94

MPCE: micronucleated polychromatic erythrocytes; NCE: normochromatic erythrocytes; PCE: polychromatic erythrocytes
Vehicle control: aqua purificata; positive control: 60 mg/kg bw cyclophosphamide
p<0.01
MPCE per 4000 PCE
dosing occurred twice in 24 hours.