A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin

Table 5

Summary of relevant hematological findings for male rats in the 90-day study.

Group		RBC	MCH	MCHC	PT	APTT
mg/kg bw/d		[x10^12/L]	[pg]	[g/L]	[sec]	[sec]
n=10
Males
Control	Mean	9.55	18.50	356.30	10.28	12.54
	SD	0.11	0.38	3.50	0.26	1.49
500	Mean	9.76	18.10	352.90	10.25	12.75
	SD	0.33	0.58	5.34	0.15	1.04
	SS
1000	Mean	9.49	18.52	354.40	10.54	13.19
	SD	0.33	0.63	5.25	0.45	1.84
	SS
2000	Mean	9.88	17.83	345.40	10.69	14.70
	SD	0.36	0.34	4.35	0.29	0.97
	SS
test for significance		U	DN	DN	U	DN
historical control range		7.52-10.21	16.6-18.8	349-379	16.5-27.3	15.2-31.8

APTT: activated partial thromboplastin time; DN: Duncan's multiple range test; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; NS: not significant; PLT: platelets; PT: prothrombin time; RBC: red blood cell count; SS: statistical significance; U: Mann-Whitney U-test versus control
= p < 0.05
= p < 0.01.